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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Zusätzlich bieten wir Ihnen DNA (Cytosine-5)-Methyltransferase 1 Kits (25) und DNA (Cytosine-5)-Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 475 products:
Human Polyclonal DNMT1 Primary Antibody für FACS, WB - ABIN387878
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody für WB - ABIN387879
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
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Fish Monoclonal DNMT1 Primary Antibody für ChIP, IP - ABIN1027706
Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989
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Fish Monoclonal DNMT1 Primary Antibody für ChIP, IP - ABIN361726
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Polyclonal DNMT1 Primary Antibody für EIA, WB - ABIN356564
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
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Human Polyclonal DNMT1 Primary Antibody für DB - ABIN389901
Siedlecki, Garcia Boy, Comagic, Schirrmacher, Wiessler, Zielenkiewicz, Suhai, Lyko: Establishment and functional validation of a structural homology model for human DNA methyltransferase 1. in Biochemical and biophysical research communications 2003
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Human Polyclonal DNMT1 Primary Antibody für EIA - ABIN358462
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008
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Human Polyclonal DNMT1 Primary Antibody für DB - ABIN389917
Dion, Lin, Hubert, Waterland, Wilson: Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. in Human molecular genetics 2008
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Human Polyclonal DNMT1 Primary Antibody für EIA - ABIN358447
Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008
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Human Polyclonal DNMT1 Primary Antibody für IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015
Dnmt1 stability requires UHRF1 (zeige UHRF1 Antikörper) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (zeige HELLS Antikörper) Is Essential for Maintaining Global DNA Methylation (zeige HELLS Antikörper) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (zeige CEBPA Antikörper) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (zeige UHRF1 Antikörper) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (zeige SUV39H1 Antikörper) and that, together, Dnmt1 and Suv39h1 (zeige SUV39H1 Antikörper) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
these results indicate that DNMT1 mediates aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells
reciprocal regulation between miR (zeige MLXIP Antikörper)-148a/152 and DNMT1 in foam cells
MUC1 (zeige MUC1 Antikörper)-C is of functional importance to induction of DNMT1 and DNMT3b (zeige DNMT3B Antikörper) and, in turn, changes in DNA methylation (zeige HELLS Antikörper) patterns in cancer cells.
This study demonstrates novel regulatory circuits involving miR (zeige MLXIP Antikörper)-148a-3p/ERBB3 (zeige ERBB3 Antikörper)/AKT2 (zeige AKT2 Antikörper)/c-myc (zeige MYC Antikörper) and DNMT1 that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
a novel molecular mechanism by which MBD4 (zeige MBD4 Antikörper) inhibits GITR (zeige TNFRSF18 Antikörper) expression in a DNMT1-dependent manner
a model in which the EZH2 (zeige EZH2 Antikörper)/HOXA11 (zeige HOXA11 Antikörper)-AS/LSD1 (zeige KDM1A Antikörper) complex and HOXA11 (zeige HOXA11 Antikörper)-AS/miR (zeige MLXIP Antikörper)-1297/EZH2 (zeige EZH2 Antikörper) cross-talk serve as critical effectors in gastric cancer tumorigenesis and progression.
Studies indicate that DNA methylation (zeige HELLS Antikörper) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A (zeige DNMT3A Antikörper) and DNMT3B (zeige DNMT3B Antikörper) carry out de novo methylation, and DNMT inhibitors have showed promising results in clinical trials of prostate cancer.
Our results suggest that epigenetic alteration of histone demethylation regulated by reduction of DNMT1 may control induction of EMT (zeige ITK Antikörper) and the CSC phenotype, which facilitates tumorigenesis in PCa (zeige FLVCR1 Antikörper) cells and has important therapeutic implications in targeting epigenetic regulation.
results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP (zeige MLXIPL Antikörper) methylation and DNMT1 variants could probably influence LDL-C to further modify ChREBP (zeige MLXIPL Antikörper) DNA methylation (zeige HELLS Antikörper)
DNMT1 overexpression is associated with Breast Cancer.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (zeige DNMT3A Antikörper), Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (zeige NLRP5 Antikörper) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (zeige MYLIP Antikörper)-29b promoter, up-regulated miR (zeige MYLIP Antikörper)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (zeige MYLIP Antikörper)-152 reduced Global DNA methylation (zeige HELLS Antikörper) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (zeige AKT1 Antikörper) and Ppar gamma (zeige PPARG Antikörper).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (zeige ASCL2 Antikörper) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (zeige MTA2 Antikörper), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (zeige VIM Antikörper) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (zeige HELLS Antikörper) and histone modification status in collaboration with MET1
VIM (zeige VIM Antikörper) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (zeige HELLS Antikörper) pathway.
Genetic studies indicate that the Polycomb (zeige CBX2 Antikörper) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (zeige HELLS Antikörper) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (zeige HELLS Antikörper) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration
SETDB1 (zeige SETDB1 Antikörper) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (zeige UHRF1 Antikörper) to hemimethylated DNA transiently disrupts SETDB1 (zeige SETDB1 Antikörper)-dependent H3K9me3 deposition.
Arx and Dnmt1 that are sufficient for achieving targeted generation of beta cells from adult pancreatic alpha cells.
The results of this study showed that DNA Methyltransferase 1 is main role of Development of the Hippocampal Dentate Gyrus in mice.
three DNA methyltransferases, Dnmt1, Dnmt3a (zeige DNMT3A Antikörper), and Dnmt3b (zeige DNMT3B Antikörper), have been identified. Dnmt3a (zeige DNMT3A Antikörper) and Dnmt3b (zeige DNMT3B Antikörper) are responsible for establishing DNA methylation (zeige HELLS Antikörper) patterns produced through their de novo-type DNA methylation (zeige HELLS Antikörper) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 Antikörper)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS Antikörper)
While lens epithelial cell survival requires DNMT1, morphologically normal lenses develop in the absence of both DNMT3A (zeige DNMT3A Antikörper) and DNMT3B (zeige DNMT3B Antikörper).
Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (zeige HELLS Antikörper) in pluripotent and differentiating cells
miR (zeige MLXIP Antikörper)-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b (zeige DNMT3B Antikörper) and SET1A (zeige SETD1A Antikörper) expression in hepatic stellate cells.
These results demonstrate that Dnmt1 and Dnmt3b (zeige DNMT3B Antikörper) cooperate to maintain DNA methylation (zeige HELLS Antikörper) and genomic integrity in the intestinal epithelium.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI