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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3B Kits (13) und DNMT3B Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 133 products:
Human Monoclonal DNMT3B Primary Antibody für ChIP, CyTOF - ABIN252478
Santoro, Li, Grummt: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. in Nature genetics 2002
Show all 97 Pubmed References
Human Polyclonal DNMT3B Primary Antibody für ICC, IF - ABIN151734
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
Show all 16 Pubmed References
Human Polyclonal DNMT3B Primary Antibody für IHC (p), WB - ABIN387884
Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: Systems-level dynamic analyses of fate change in murine embryonic stem cells. in Nature 2009
Show all 13 Pubmed References
Human Polyclonal DNMT3B Primary Antibody für ChIP, IHC - ABIN152675
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Polyclonal DNMT3B Primary Antibody für IF (p), IHC (p) - ABIN727623
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Human Monoclonal DNMT3B Primary Antibody für ChIP, WB - ABIN2668954
Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. in Molecular cancer research : MCR 2013
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Human Polyclonal DNMT3B Primary Antibody für ICC, IF - ABIN314552
Fűri, Sipos, Spisák, Kiszner, Wichmann, Schöller, Tulassay, Műzes, Molnár: Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status. in TheScientificWorldJournal 2014
Human Monoclonal DNMT3B Primary Antibody für WB - ABIN2668953
Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. in Nucleic acids research 2011
Mouse (Murine) Polyclonal DNMT3B Primary Antibody für WB - ABIN2668253
Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013
dnmt7 specifically methylates no tail gene in the genome
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Antikörper) content are rather a function of time, and not a genetic component.
DNMT1 (zeige DNMT1 Antikörper), DNMT3A (zeige DNMT3A Antikörper), and DNMT3B were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (zeige DNMT1 Antikörper) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (zeige DNMT1 Antikörper) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (zeige DNMT1 Antikörper) A201G gene polymorphi
report the first crystal structure of the DNMT3B PWWP domain-H3K36me3 complex.
Results continue to establish ANG (zeige ANG Antikörper) as an oncoprotein and further reveal that ANG (zeige ANG Antikörper) contributes to oncogenesis by the activation of MMP2 (zeige MMP2 Antikörper) through modulation of DNMT3b functions.
found association between DNMT3B rs2424913 in T allele carriers with Parkinson's disease
H19 (zeige NCKAP1 Antikörper) might function as ceRNA (competing endogenous RNA) for miR (zeige MLXIP Antikörper)-29b-3p and relieve the suppression for DNMT3B, which led to EMT (zeige ITK Antikörper) and metastasis of bladder cancer (BC). Our findings highlight a novel mechanism of H19 (zeige NCKAP1 Antikörper) in progression of BC and provide H19 (zeige NCKAP1 Antikörper)/miR (zeige MLXIP Antikörper)-29b-3p/DNMT3B axis as a promising therapeutic target for BC.
DNMT1 (zeige DNMT1 Antikörper) up-regulation induced by IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling was indispensable for IL-6 (zeige IL6 Antikörper)-mediated hepaCAM (zeige HEPACAM Antikörper) loss in renal cell carcinoma (zeige MOK Antikörper) (RCC (zeige XRCC1 Antikörper)) cell lines ACHN (zeige LARP6 Antikörper) and 769-P, while DNMT3b up-regulation was crucial for hepaCAM (zeige HEPACAM Antikörper) loss in A498.
A Methylated DNA Quantification Kit was used to quantify global DNA methylation (zeige HELLS Antikörper), and single nucleotide polymorphisms (SNPs) in DNMT3A (zeige DNMT3A Antikörper) (rs36012910, rs1550117, and R882) and DNMT3B (rs1569686, rs2424909, and rs2424913) were identified using the restriction fragment length polymorphism method
A novel homozygous missense mutation, Ala585Thr, was found in DNMT3B.
Definitive diagnosis should be done using metaphase analysis to identify centromeric instability and/or ICF disease gene mutations analysis. Bilateral VUR may occur in ICF patients with homozygous DNMT3B mutations in early childhood. Renal ultrasonography should be included in ICF1 patients for the screening of congenital anomalies.
DNMT 3B was upregulated in invasive subclones and exerted on influence of E-cad gene methylation.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Antikörper) and E-CADHERIN (zeige CDH1 Antikörper), and the pluripotency markers, DNMT3B and CRIPTO (zeige TDGF1 Antikörper).
Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
The expression levels of DNMT3a (zeige DNMT3A Antikörper) and DNMT3b were associated with several beef quality traits.
a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.
Together, this study described the regulation of Chk2 (zeige CHEK2 Antikörper) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (zeige CHEK2 Antikörper) during neuronal differentiation, which is independent of its previously known function in DNA damage response.
in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation
three DNA methyltransferases, Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a (zeige DNMT3A Antikörper), and Dnmt3b, have been identified. Dnmt3a (zeige DNMT3A Antikörper) and Dnmt3b are responsible for establishing DNA methylation (zeige HELLS Antikörper) patterns produced through their de novo-type DNA methylation (zeige HELLS Antikörper) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 Antikörper)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS Antikörper)
While lens epithelial cell survival requires DNMT1 (zeige DNMT1 Antikörper), morphologically normal lenses develop in the absence of both DNMT3A (zeige DNMT3A Antikörper) and DNMT3B.
Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.
a miR (zeige MLXIP Antikörper)-125b-DNMT3b-p53 (zeige TP53 Antikörper) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.
miR (zeige MLXIP Antikörper)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (zeige DNMT1 Antikörper), DNMT3b and SET1A (zeige SETD1A Antikörper) expression in hepatic stellate cells.
Loss of DNMT3B results in hypomethylation of the miR (zeige MLXIP Antikörper)-196b promoter and increased miR (zeige MLXIP Antikörper)-196b expression, which directly targets the mTORC2 (zeige CRTC2 Antikörper) component Rictor (zeige RICTOR Antikörper).
The findings define PRMT7 (zeige PRMT7 Antikörper) as a regulator of the DNMT3b/p21 (zeige D4S234E Antikörper) axis required to maintain muscle stem cell regenerative capacity.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
DNA (cytosine-5)-methyltransferase 3B
, DNA (cytosine-5-)-methyltransferase 3 beta
, DNA cytosine-5 methyltransferase 3 beta
, DNA (cytosine-5)-methyltransferase 3B-like
, DNA methyl transferase beta
, DNA methyltransferase 3B
, DNA MTase HsaIIIB
, DNA methyltransferase HsaIIIB
, DNA (cytosine-5-)-methyltransferase 3 beta, like
, DNA (cytosine-5-)-methyltransferase 7
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB