Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Zusätzlich bieten wir Ihnen DDX41 Kits (10) und DDX41 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 72 products:
Human Polyclonal DDX41 Primary Antibody für WB - ABIN1881255
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
Show all 3 Pubmed References
Cow (Bovine) Polyclonal DDX41 Primary Antibody für WB - ABIN2775230
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Human Monoclonal DDX41 Primary Antibody für IF, ELISA - ABIN565608
Omura, Oikawa, Nakane, Kato, Ishii, Ishitani, Tokunaga, Nureki: Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. in Scientific reports 2016
DDX41 mutations lead to development of high-risk myelodysplastic syndrome.(review)
An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (zeige BCL11A Antikörper) (MDS (zeige PAFAH1B1 Antikörper)/AML (zeige RUNX1 Antikörper)) patients.
data demonstrate that DDX41 suppresses p21 (zeige CDKN1A Antikörper) translation without disturbing the function of p53 (zeige TP53 Antikörper) to directly induce p21 (zeige CDKN1A Antikörper) mRNA expression, this process indirectly requires p53 (zeige TP53 Antikörper), perhaps in the form of another p53 (zeige TP53 Antikörper) target gene or as a still undefined posttranscriptional function of p53 (zeige TP53 Antikörper).
This study uncovered a pathogenic role of p.R525H DDX41 in the slow growth rate of tumor cells. Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML (zeige RUNX1 Antikörper).
This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations.
corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
results suggest a mechanism whereby c-di-GMP (zeige NT5C2 Antikörper) and c-di-AMP (zeige APRT Antikörper) are detected by DDX41, which forms a complex with STING to signal to TBK1 (zeige TBK1 Antikörper)-IRF3 (zeige IRF3 Antikörper) and activate the interferon (zeige IFNA Antikörper) response
DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 (zeige SNX2 Antikörper) suggesting that PX domains may also participate in protein-protein interaction.
Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK (zeige BTK Antikörper) phosphorylation site.
TRIM21 (zeige TRIM21 Antikörper) is an interferon (zeige IFNA Antikörper)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
, DEAD-box protein abstrakt
, probable ATP-dependent RNA helicase DDX41-like
, DEAD box protein 41
, DEAD box protein abstrakt homolog
, probable ATP-dependent RNA helicase DDX41
, putative RNA helicase