anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Antikörper

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Zusätzlich bieten wir Ihnen CTLA4 Proteine (83) und CTLA4 Kits (49) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CTLA4 12477 P09793
CTLA4 1493 P16410
CTLA4 63835  
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Top anti-CTLA4 Antikörper auf antikoerper-online.de

Showing 10 out of 453 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Ratte Maus PE FACS Staining of rat CD152 transfected cell line following permeabilisation. 100 Tests Anmelden zum Anzeigen 6 bis 8 Tage
$511.50
Details
Maus Ratte Unkonjugiert CyTOF, FACS, Neut, WB CTLA-4 Inhibition of B7-1/CD80-induced IL-2 Secretion and Neutralization by Mouse CTLA-4 Antibody. Recombinant Mouse CTLA-4 Fc Chimera. 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$328.90
Details
Maus Ratte Fluorescein FACS 100 Tests Anmelden zum Anzeigen 8 bis 9 Tage
$281.75
Details
Human Kaninchen Unkonjugiert IHC (p), WB IDDM12 Antibody (N-term)  western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the IDDM12 antibody detected the IDDM12 protein (arrow). IDDM12 Antibody (N-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate  carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the IDDM12 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus FITC FACS 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin fixed and paraffin embedded human prostate carcinoma reacted with CD152 / CTLA4 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of CD152 / CTLA4 Antibody (N-term) in WiDr cell line lysates (35ug/lane). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Ziege PE FACS Detection of CTLA-4 in NS0 Mouse Cell Line Transfected with Human CTLA-4 and eGFP by Flow Cytometry. NS0 mouse myeloma cell line transfected with human CTLA-4 and eGFP was stained with (A) Goat Anti-Human CTLA-4 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Anmelden zum Anzeigen 8 bis 9 Tage
$357.65
Details
Human Kaninchen Unkonjugiert WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Mouse lung lysate probed with Anti CTLA4 Polyclonal Antibody, Unconjugated (ABIN1714514) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 34kD. Observed band size: 34kD 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$318.45
Details
Human Ziege Unkonjugiert CyTOF, FACS, ICC, WB Detection of CTLA-4 in NS0 Mouse Cell Line Co-transfected with CTLA-4 and eGFP by Flow Cytometry. NS0 mouse myeloma cell line co-transfected with human CTLA-4 and eGFP was stained with either (A) Goat Anti-Human CTLA-4 Antigen Affinity-purified Polyclonal Antibody. CTLA-4 in Human Peripheral Blood Mononuclear Cells. CTLA-4 was detected in immersion fixed human peripheral blood mononuclear cells treated with treated with PMA and calcium ionomycin using Goat Anti-Human CTLA-4 Antigen Affinity-purified Polyclonal Antibody  at 15 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLightsル 557-conjugated Anti-Goat IgG Secondary Antibody (red 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$433.55
Details
Ratte Maus FITC FACS   0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$313.50
Details

CTLA4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-CTLA4 Antikörper

  1. Mouse (Murine) Monoclonal CTLA4 Primary Antibody für BR, FACS - ABIN1176976 : Kearney, Walunas, Karr, Morton, Loh, Bluestone, Jenkins: Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 18 Pubmed References

  2. Mouse (Murine) Monoclonal CTLA4 Primary Antibody für FACS, IP - ABIN2688989 : Harper, Balzano, Rouvier, Mattéi, Luciani, Golstein: CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. in Journal of immunology (Baltimore, Md. : 1950) 1991 (PubMed)
    Show all 17 Pubmed References

  3. Mouse (Murine) Monoclonal CTLA4 Primary Antibody für BR, FACS - ABIN1176977 : Alegre, Noel, Eisfelder, Chuang, Clark, Reiner, Thompson: Regulation of surface and intracellular expression of CTLA4 on mouse T cells. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 15 Pubmed References

  4. Human Monoclonal CTLA4 Primary Antibody für IHC (f), ICC - ABIN1981896 : Steiner, Moosig, Csernok, Selleng, Gross, Fleischer, Bröker: Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. in Clinical and experimental immunology 2001 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal CTLA4 Primary Antibody für IHC (f), ICC - ABIN2749015 : Chin, Chu, Chen, Hsu, Weng, Chu: Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands. in BMC biotechnology 2007 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal CTLA4 Primary Antibody für FACS - ABIN2688990 : Guesdon, Ternynck, Avrameas: The use of avidin-biotin interaction in immunoenzymatic techniques. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1979 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal CTLA4 Primary Antibody für Func, FACS - ABIN610405 : Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ... in The Journal of cell biology 1993 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal CTLA4 Primary Antibody für Func, FACS - ABIN610404 : Chitaev, Troyanovsky: Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation. in The Journal of cell biology 1998 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal CTLA4 Primary Antibody für Func, FACS - ABIN1177323 : Kuiper, Brouwer, Linsley, van Lier: Activated T cells can induce high levels of CTLA-4 expression on B cells. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal CTLA4 Primary Antibody für IHC (f), ICC - ABIN1981873 : Steiner, Waase, Rau, Dietrich, Fleischer, Bröker: Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. in Clinical and experimental immunology 1999 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen CTLA4 Interaktionspartner

Rhesus Monkey Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaktionspartner

  1. Data show that CTLA-4(+)PD-1 (zeige PDCD1 Antikörper)(-) memory CD4 (zeige CD4 Antikörper)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (zeige GUSB Antikörper), and contained replication-competent and infectious virus.

Mouse (Murine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaktionspartner

  1. Tregs were observed to regulate CD4 (zeige CD4 Antikörper)(+), but not CD8 (zeige CD8A Antikörper)(+), T cell infiltration into tumors through a CTLA-4/CD80 (zeige CD80 Antikörper) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (zeige CD80 Antikörper) was sufficient to induce CD4 (zeige CD4 Antikörper) T cell infiltration into tumors.

  2. These results suggest that CD44 (zeige CD44 Antikörper)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.

  3. data suggest that increased expression of checkpoint blockade molecules PD-1 (zeige PDCD1 Antikörper) and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients

  4. Treg cells expand in both humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and follicular T helper (TFH)-B cell interactions in germinal centers. Mechanistically, Treg cells function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).

  5. CTLA-4 expressed by FOXP3 (zeige FOXP3 Antikörper)(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.

  6. results are consistent with a complex pathway in which CD28 (zeige CD28 Antikörper) is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80 (zeige CD80 Antikörper)/CD86 (zeige CD86 Antikörper)

  7. CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.

  8. this study shows that miR (zeige MLXIP Antikörper)-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4 (zeige CD4 Antikörper)+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression

  9. CTLA-4 regulates atherosclerosis by suppressing proatherogenic immune responses.

  10. Data suggest enhanced clinical benefit from combining CTLA-4 antigen blockade with poxvirus-based active immunotherapy.

Human Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaktionspartner

  1. These results indicate that CTLA-4 expression in the tumor environment of esophageal carcinoma is associated with poorer prognosis

  2. Of several immunotherapies being investigated, antibodies that target the programmed cell death protein-1 (zeige PDCD1 Antikörper) (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte antigen-4 (ipilimumab) immune checkpoint pathways are among the most promising for patients with Small cell lung cancer (SCLC), and are the focus of this review.

  3. In oncology, the two main classes of Checkpoint inhibitors (CPI), which are the most advanced in clinical development are the anti-CTLA-4 and anti-PD-1/PD-L1 antibodies (Abs). Three of these Abs have been approved by the FDA for clinical use.CPI can have efficacy across several types of cancer.

  4. No significant associations with RHD (zeige RHD Antikörper) were found for the IL1RN (zeige IL1RN Antikörper) rs447713 and CTLA4 rs3087243 SNPs.

  5. Data show that interleukin-21 (zeige IL21 Antikörper)-primed cytotoxic T-cell lymphocytes (CTL) with cytotoxic T-lymphocyte associated protein 4 (CTLA-4) blockade is safe and produces durable clinical responses.

  6. Analysis of copy number alterations identified a higher burden of copy number loss in nonresponders to CTLA-4 and PD-1 (zeige PDCD1 Antikörper) blockade and found that it was associated with decreased expression of genes in immune-related pathways.

  7. the upregulation of others syncytial molecules, including LAG3 (zeige LAG3 Antikörper), CTLA4, CD28 (zeige CD28 Antikörper) and CD3 (zeige CD3 Antikörper), assisting the formation of syncytia with APC (zeige APC Antikörper) cells.

  8. Tregs were observed to regulate CD4 (zeige CD4 Antikörper)(+), but not CD8 (zeige CD8A Antikörper)(+), T cell infiltration into tumors through a CTLA-4/CD80 (zeige CD80 Antikörper) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (zeige CD80 Antikörper) was sufficient to induce CD4 (zeige CD4 Antikörper) T cell infiltration into tumors.

  9. Our study reports a novel association of SNPs within CD86 (zeige CD86 Antikörper) and CTLA4 genes with pemphigus. The CD86 (zeige CD86 Antikörper) rs1129055 A allele appears to confer susceptibility to Pemphigus vulgaris (zeige DSG3 Antikörper) but not to pemphigus foliaceus (zeige DSG1 Antikörper).

  10. nasopharyngeal carcinoma patients with high tumor CTLA-4 expression had a poorer prognosis than those with low expression.

Pig (Porcine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaktionspartner

  1. Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (zeige CD80 Antikörper)-positive cells.

Cow (Bovine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaktionspartner

  1. The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (zeige ZAP70 Antikörper) were decreased in CD4 (zeige CD4 Antikörper)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

  2. These results suggested that the expression level of CTLA-4 in CD4 (zeige CD4 Antikörper)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.

  3. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (zeige FOXP3 Antikörper) and CTLA4.

CTLA4 Antigen-Profil

Protein Überblick

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Genbezeichner und Symbole assoziert mit CTLA4

  • cytotoxic T-lymphocyte associated protein 4 (CTLA4) Antikörper
  • cytotoxic T-lymphocyte-associated protein 4 (Ctla4) Antikörper
  • CD Antikörper
  • Cd152 Antikörper
  • CELIAC3 Antikörper
  • Ctla-4 Antikörper
  • CTLA4 Antikörper
  • GRD4 Antikörper
  • GSE Antikörper
  • IDDM12 Antikörper
  • Ly-56 Antikörper
  • sCTLA4 Antikörper

Bezeichner auf Proteinebene für CTLA4

cytotoxic T-lymphocyte-associated protein 4 precursor , CD152 protein , cytotoxic T-lymphocyte protein 4 , cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM , cytotoxic T-lymphocyte-associated protein 4 , costimulatory molecule B7 receptor , cytotoxic T lymphocyte-associated antigen 4 , CD152 antigen , cytotoxic T-lymphocyte-associated antigen 4 , CD152 isoform , celiac disease 3 , cytotoxic T lymphocyte associated antigen 4 short spliced form , cytotoxic T-lymphocyte antigen 4 , cytotoxic T-lymphocyte-associated serine esterase-4 , ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 , soluble form , transmembrane form , CTLA-4 , cytotoxic T lymphocyte-associated protein 4 , costimulatory molecule B7 receptor CD152

GENE ID SPEZIES
443040 Ovis aries
705673 Macaca mulatta
100222727 Taeniopygia guttata
424106 Gallus gallus
470619 Pan troglodytes
493743 Felis catus
100126716 Papio anubis
12477 Mus musculus
1493 Homo sapiens
63835 Rattus norvegicus
100009412 Oryctolagus cuniculus
397286 Sus scrofa
403696 Canis lupus familiaris
281732 Bos taurus
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