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The protein encoded by CYTH4 is a member of the PSCD family. Zusätzlich bieten wir Ihnen Cytohesin 4 Antikörper (61) und Cytohesin 4 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
This is the first evidence of a link between a primate-specific short tandem repeat of promoter of CYTH4 and a major psychiatric disorder in human
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar.
, PH, SEC7 and coiled-coil domain-containing protein 4
, pleckstrin homology, Sec7 and coiled-coil domains 4
, pleckstrin homology, Sec7 and coiled/coil domains 4