Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Proteine (CYP46A1)

CYP46A1 encodes a member of the cytochrome P450 superfamily of enzymes. Zusätzlich bieten wir Ihnen Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Antikörper (85) und Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CYP46A1 10858 Q9Y6A2
CYP46A1 13116 Q9WVK8
Ratte CYP46A1 CYP46A1 362782  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
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CYP46A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Interaktionspartnern

Human Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Interaktionspartner

  1. Data suggest that CYP46A1, the enzyme responsible for the majority of cholesterol elimination from the brain, exhibits activation by neurotransmitters, L-glutamate (zeige GRIN1 Proteine), L-aspartate, gamma-aminobutyric acid, and acetylcholine; L-glutamate (zeige GRIN1 Proteine)-induced CYP46A1 activation may be of physiological relevance.

  2. CYP46A1 rs4900442 genetic polymorphism was associated with increased risk of Alzheimer disease in the Chinese population, but no evidences were detected in Caucasian population.

  3. Findings of this study suggest that CYP46A1 gene and PPARgamma2 (zeige PPARG Proteine) gene polymorphisms can be a predictive marker for early identification of population at risk of primary open angle glaucoma (POAG).

  4. hippocampal CYP46A1 protein and 24S-hydroxycholesterol levels were reduced in a mouse model of Alzheimer's Disease-like Tau neuropathology

  5. under conditions of membrane cholesterol reduction by increased CYP46A1 expression, neurons increase isoprenoid synthesis and sGTPase prenylation. This leads to a reduction in liver X receptor activity

  6. Human CYP46A1 oxidizes 7-dehydrocholesterol to 24-hydroxy-7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol.

  7. While there were no differences in cognitive performance between participants with and those without metabolic syndrome, ApoE (zeige APOE Proteine) and CYP46 genotypes did correlate with mental manipulation scores.

  8. results of meta-analysis suggested that CYP46A1 rs754203 is a minor risk factor for Alzheimer's disease

  9. An meta-analysis has successfully proved that CC genotype of the CYP46A1 T/C polymorphism could increase the risk of Alzheimer's disease.

  10. A meta-analysis indicates that the CYP46 gene SNP rs754203 is not significantly associated with sporadic Alzheimer's disease susceptibility in Chinese Han populations.

Cow (Bovine) Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Interaktionspartner

  1. EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.

  2. analysis of binding of the cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1

Mouse (Murine) Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Interaktionspartner

  1. Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model.

  2. under conditions of membrane cholesterol reduction by increased CYP46A1 expression, neurons increase isoprenoid synthesis and sGTPase prenylation. This leads to a reduction in liver X receptor activity

  3. EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.

  4. the CYP46 gene locus may predispose to Alzheimer's disease by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain.

  5. The expression of CYP46A1, as well as other cytochrome P450s involved in cholesterol homeostasis, are potently regulated by histone acetylation status.

Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Protein Überblick

Protein Überblick

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Genbezeichner und Symbole assoziert mit CYP46A1

  • cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1)
  • cytochrome P450, family 46, subfamily A, polypeptide 1 (cyp46a1)
  • cytochrome P450, family 46 (cyp46a1)
  • cytochrome P450 46A1 (PTRG_08343)
  • cytochrome P450 46A1 (PTRG_09667)
  • cholesterol 24-hydroxylase (Sgly_1093)
  • cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1)
  • CP46 Protein
  • Cyp46 Protein
  • CYP46A1 Protein
  • MGC147389 Protein
  • zgc:109896 Protein

Bezeichner auf Proteinebene für CYP46A1

cholesterol 24-hydroxylase , cytochrome P450, family 46, subfamily A, polypeptide 1 , cytochrome P450, family 46 , cytochrome P450 46A1 , CH24H , cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) , cholesterol-24S-hydroxylase , cholestrol 24-hydroxylase , cytochrome P450, 46 (cholesterol 24-hydroxylase) , cytochrome P450, 46a1 (cholesterol 24-hydroxylase)

GENE ID SPEZIES
423450 Gallus gallus
453154 Pan troglodytes
553543 Danio rerio
780005 Xenopus (Silurana) tropicalis
100145328 Xenopus (Silurana) tropicalis
6346625 Pyrenophora tritici-repentis Pt-1C-BFP
6347960 Pyrenophora tritici-repentis Pt-1C-BFP
10248273 Syntrophobotulus glycolicus DSM 8271
10858 Homo sapiens
379470 Xenopus laevis
506438 Bos taurus
13116 Mus musculus
362782 Rattus norvegicus
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