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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Zusätzlich bieten wir Ihnen CST6 Antikörper (90) und CST6 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 16 products:
Mouse (Murine) CST6 Protein expressed in Human Cells - ABIN2008402
Schagdarsurengin, Pfeifer, Dammann: Frequent epigenetic inactivation of cystatin M in breast carcinoma. in Oncogene 2007
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Human CST6 Protein expressed in Human Cells - ABIN2002849
Sotiropoulou, Anisowicz, Sager: Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. in The Journal of biological chemistry 1997
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Human CST6 Protein expressed in Escherichia coli (E. coli) - ABIN667941
Ni, Abrahamson, Zhang, Fernandez, Grubb, Su, Yu, Li, Parmelee, Xing, Coleman, Gentz, Thotakura, Nguyen, Hesselberg, Gentz: Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. in The Journal of biological chemistry 1997
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Data suggest that melanoma cells internalize/absorb cystatin C (zeige CST3 Proteine) from culture media, leading to increased intracellular cystatin C (zeige CST3 Proteine) levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain (zeige LGMN Proteine) activity is pronounced.
Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB (zeige NFKB1 Proteine).
Low CST6 expression is associated with breast cancer.
Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs.
The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals.
Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain (zeige LGMN Proteine) activity.
The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival.
An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor (zeige ESR1 Proteine), progesterone receptor (zeige PGR Proteine), and HER4 (zeige ERBB4 Proteine) in tumor tissues was found
the level of cystatin E/M regulates legumain (zeige LGMN Proteine) activity and hence the invasive potential of human melanoma cells
CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis
conclude that a tightly regulated balance between cathepsin L (zeige CTSL1 PLURAL_@34956@) and cystatin M/E is essential for tissue integrity in epidermis, hair follicles, and corneal epithelium
cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.
, cystatin M
, cystatin 6
, cystatin M/E
, cysteine proteinase inhibitor
, harlequin ichthyosis
, harlequin ichthysosis
, cystatin N