Cystatin E/M Proteine (CST6)

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Zusätzlich bieten wir Ihnen CST6 Antikörper (90) und CST6 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CST6 1474 Q15828
CST6 73720  
Ratte CST6 CST6 171096  
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Top CST6 Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
HOST_Human Cells Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 bis 15 Tage
387,62 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
523,81 €
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HOST_Mammalian Cells Maus His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
523,81 €
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
203,70 €
Details
HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
285,71 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
579,05 €
Details

CST6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine) , ,

Am meisten referenzierte CST6 Proteine

  1. Mouse (Murine) CST6 Protein expressed in Human Cells - ABIN2008402 : Schagdarsurengin, Pfeifer, Dammann: Frequent epigenetic inactivation of cystatin M in breast carcinoma. in Oncogene 2007 (PubMed)
    Zeige alle 5 Referenzen für 2008402

  2. Human CST6 Protein expressed in Human Cells - ABIN2002849 : Sotiropoulou, Anisowicz, Sager: Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. in The Journal of biological chemistry 1997 (PubMed)
    Zeige alle 5 Referenzen für 2002849

  3. Human CST6 Protein expressed in Escherichia coli (E. coli) - ABIN667941 : Ni, Abrahamson, Zhang, Fernandez, Grubb, Su, Yu, Li, Parmelee, Xing, Coleman, Gentz, Thotakura, Nguyen, Hesselberg, Gentz: Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. in The Journal of biological chemistry 1997 (PubMed)
    Zeige alle 2 Referenzen für 667941

Weitere Proteine zu Cystatin E/M (CST6) Interaktionspartnern

Human Cystatin E/M (CST6) Interaktionspartner

  1. Data suggest that melanoma cells internalize/absorb cystatin C (zeige CST3 Proteine) from culture media, leading to increased intracellular cystatin C (zeige CST3 Proteine) levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain (zeige LGMN Proteine) activity is pronounced.

  2. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB (zeige NFKB1 Proteine).

  3. Low CST6 expression is associated with breast cancer.

  4. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs.

  5. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals.

  6. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain (zeige LGMN Proteine) activity.

  7. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival.

  8. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor (zeige ESR1 Proteine), progesterone receptor (zeige PGR Proteine), and HER4 (zeige ERBB4 Proteine) in tumor tissues was found

  9. the level of cystatin E/M regulates legumain (zeige LGMN Proteine) activity and hence the invasive potential of human melanoma cells

  10. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis

Mouse (Murine) Cystatin E/M (CST6) Interaktionspartner

  1. conclude that a tightly regulated balance between cathepsin L (zeige CTSL1 PLURAL_@34956@) and cystatin M/E is essential for tissue integrity in epidermis, hair follicles, and corneal epithelium

  2. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]

CST6 Protein Überblick

Protein Überblick

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Genbezeichner und Symbole assoziert mit Cystatin E/M Proteine (CST6)

  • cystatin E/M (CST6)
  • cystatin E/M (Cst6)
  • 1110017E11Rik Protein
  • CST6 Protein
  • ichq Protein
  • N28197 Protein

Bezeichner auf Proteinebene für Cystatin E/M Proteine (CST6)

cystatin E/M , cystatin M , cystatin-M , cystatin 6 , cystatin M/E , cystatin-6 , cystatin-E , cysteine proteinase inhibitor , harlequin ichthyosis , harlequin ichthysosis , cystatin N

GENE ID SPEZIES
466668 Pan troglodytes
503685 Bos taurus
714999 Macaca mulatta
1474 Homo sapiens
483719 Canis lupus familiaris
73720 Mus musculus
171096 Rattus norvegicus
Ausgewählte Anbieter für CST6 Proteine (CST6)
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