Cystatin E/M Proteine (CST6)

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Zusätzlich bieten wir Ihnen CST6 Antikörper (90) und CST6 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CST6 1474 Q15828
CST6 73720  
Ratte CST6 CST6 171096  
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Top CST6 Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$407.00
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
Details
Mammalian Cells Maus His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$130.00
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$608.00
Details

CST6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine) , ,

Weitere Proteine zu Cystatin E/M (CST6) Interaktionspartnern

Human Cystatin E/M (CST6) Interaktionspartner

  1. Data suggest that melanoma cells internalize/absorb cystatin C (zeige CST3 Proteine) from culture media, leading to increased intracellular cystatin C (zeige CST3 Proteine) levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain (zeige LGMN Proteine) activity is pronounced.

  2. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB (zeige NFKB1 Proteine).

  3. Low CST6 expression is associated with breast cancer.

  4. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs.

  5. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals.

  6. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain (zeige LGMN Proteine) activity.

  7. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival.

  8. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor (zeige ESR1 Proteine), progesterone receptor (zeige PGR Proteine), and HER4 (zeige ERBB4 Proteine) in tumor tissues was found

  9. the level of cystatin E/M regulates legumain (zeige LGMN Proteine) activity and hence the invasive potential of human melanoma cells

  10. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis

Mouse (Murine) Cystatin E/M (CST6) Interaktionspartner

  1. Using quenched activity-based probes, we identified mouse cathepsin B (CtsB (zeige CTSB Proteine)), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6

  2. conclude that a tightly regulated balance between cathepsin L (zeige CTSL1 Proteine) and cystatin M/E is essential for tissue integrity in epidermis, hair follicles, and corneal epithelium

  3. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]

CST6 Protein Überblick

Protein Überblick

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Genbezeichner und Symbole assoziert mit Cystatin E/M Proteine (CST6)

  • cystatin E/M (CST6)
  • cystatin E/M (Cst6)
  • 1110017E11Rik Protein
  • CST6 Protein
  • ichq Protein
  • N28197 Protein

Bezeichner auf Proteinebene für Cystatin E/M Proteine (CST6)

cystatin E/M , cystatin M , cystatin-M , cystatin 6 , cystatin M/E , cystatin-6 , cystatin-E , cysteine proteinase inhibitor , harlequin ichthyosis , harlequin ichthysosis , cystatin N

GENE ID SPEZIES
466668 Pan troglodytes
503685 Bos taurus
714999 Macaca mulatta
1474 Homo sapiens
483719 Canis lupus familiaris
73720 Mus musculus
171096 Rattus norvegicus
Ausgewählte Anbieter für CST6 Proteine (CST6)
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