anti-Cyclin G Associated Kinase (GAK) Antikörper

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Zusätzlich bieten wir Ihnen GAK Kits (15) und GAK Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GAK 2580 O14976
GAK 231580 Q99KY4
GAK 81659 P97874
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Showing 10 out of 96 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of GAK (arrow) using GAK Antibody (C-term) (ABIN392633). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the GAK gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-hGAK-G30 Pab (ABIN392632) in mouse heart tissue lysate. hGAK-G30(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from 293 cells, using GAK Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of GAK staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of GAK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
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Human Kaninchen Unkonjugiert IHC (p), ELISA, WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: GAK Antibody [NBP1-86388] - Staining of human rectum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details

GAK Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen GAK Interaktionspartner

Human Cyclin G Associated Kinase (GAK) Interaktionspartner

  1. We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7 (zeige FBXW7 Antikörper)-GAK inhibition increases multipolar mitoses

  2. GAK gene expression is increased in Parkinson disease

  3. We filtered four OSCC genes including SERPINB9 (zeige SERPINB9 Antikörper), SERPINE2 (zeige SERPINE2 Antikörper), GAK, and HSP90B1 (zeige HSP90B1 Antikörper) through the gene global prioritization score (P < 0.005).

  4. This meta-analysis suggests that GAK rs1564282 C/T polymorphism is associated with increased susceptibility to Parkinson's disease--{REVIEW}

  5. Data indicated that GBA (zeige GBA Antikörper) and TMEM175/GAK significantly alter age at onset in PD.

  6. AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR (zeige EGFR Antikörper), AP2M1 (zeige AP2M1 Antikörper), and NUMB (zeige NUMB Antikörper), and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively.

  7. The effects of rs11248051 and rs1564282 variants of GAK, and the rs3129882 variant of HLA-DRA (zeige HLA-DRA Antikörper), were investigated in Parkinson's disease patients.

  8. GAK apo (zeige C9orf3 Antikörper) structure reveals a dimeric inactive state of the catalytic domain mediated by an unusual activation segment interaction.

  9. Cyclin-G-associated kinase is a binding partners of LRRK2 (zeige LRRK2 Antikörper), a candidate genes for risk for sporadic Parkinson disease, and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system.

  10. Dominant negative mutants of IRAK4 (zeige IRAK4 Antikörper) and GAK show strong apoptotic effects in A498 cells under anoxia.

Mouse (Murine) Cyclin G Associated Kinase (GAK) Interaktionspartner

  1. PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.

  2. GAK knockout causes senescence and centrosome duplication in MEF cells.

  3. These results suggest that inhibition of GAK by gefitinib may cause pulmonary alveolar dysfunction.

  4. GAK deletion blocks development and causes lethality in adult animals by disrupting clathrin-mediated endocytosis

GAK Antigen-Profil

Protein Überblick

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.

Genbezeichner und Symbole assoziert mit GAK

  • cyclin G associated kinase (GAK) Antikörper
  • cyclin G associated kinase (gak) Antikörper
  • cyclin G associated kinase (Gak) Antikörper
  • D130045N16Rik Antikörper
  • DKFZp469F1313 Antikörper
  • DNAJ26 Antikörper
  • DNAJC26 Antikörper
  • gak Antikörper
  • MGC172462 Antikörper
  • si:dkeyp-1e8.1 Antikörper

Bezeichner auf Proteinebene für GAK

cyclin G associated kinase , cyclin-G-associated kinase-like , auxilin-2 , cyclin-G-associated kinase , cyclin G-associated kinase

GENE ID SPEZIES
100051853 Equus caballus
100171982 Pongo abelii
549104 Xenopus (Silurana) tropicalis
461048 Pan troglodytes
703406 Macaca mulatta
571705 Danio rerio
100482527 Ailuropoda melanoleuca
2580 Homo sapiens
231580 Mus musculus
81659 Rattus norvegicus
427291 Gallus gallus
479133 Canis lupus familiaris
511296 Bos taurus
101106688 Ovis aries
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