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CUL4B is a member of the cullin family. Zusätzlich bieten wir Ihnen Cullin 4B Antikörper (95) und Cullin 4B Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Results show that cul4a (zeige CUL4A ELISA Kits) but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
The CUL4B interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation.
This study found that microRNA-194 (miR (zeige MLXIP ELISA Kits)-194) and CUL4B protein were inversely correlated in cancer specimens and demonstrated that miR (zeige MLXIP ELISA Kits)-194 could downregulate CUL4B by directly targeting its 3'-UTR (zeige UTS2R ELISA Kits).
findings revealed that CUL4A (zeige CUL4A ELISA Kits) and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes
CUL4B regulates protein turnover and homeostasis in response to dopamine stimulation.
CUL4B protein levels in human subcutaneous adipose tissue is negatively correlated with body mass index.
these results suggest that knockdown of CUL4B inhibited the proliferation and invasion through suppressing the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway in NSCLC cells. Therefore, CUL4B may represent a novel therapeutic target for the treatment of NSCLC.
these results showed that knockdown of CUL4B inhibit proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway
Our data are consistent with the idea that the CUL4A (zeige CUL4A ELISA Kits)/B-DDB1-CRBN (zeige CRBN ELISA Kits) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (zeige CLCN1 ELISA Kits) channels.
FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
results established a critical role of CUL4B in negatively regulating the p53 (zeige TP53 ELISA Kits)-ROS (zeige ROS1 ELISA Kits) positive feedback loop that drives cellular senescence
A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions
Adipocyte-specific Cul4b knockout (AKO) mice being fed a high-fat diet exhibited increased body fat accumulation that was mediated by increased adipogenesis. However, AKO mice showed improved metabolic phenotypes, including increased insulin (zeige INS ELISA Kits) sensitivity and glucose tolerance. Correspondingly, there was a decreased inflammatory response in adipose tissues of AKO mice.
CUL4B as a key regulator of post-meiotic sperm morphogenesis
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice
Ptgds (zeige PTGDS ELISA Kits) is targeted and repressed by the CUL4B/PRC2 complex.
CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice.
Data indicate a role of cullin family, CUL4B, in the immune system.
Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 (zeige COPS5 ELISA Kits) accumulation.
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.