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CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Zusätzlich bieten wir Ihnen Cullin 4A Antikörper (77) und Cullin 4A Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Results show that cul4a but not cul4b (zeige CUL4B ELISA Kits) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
The CUL4A interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation.
knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients
findings revealed that CUL4A and CUL4B (zeige CUL4B ELISA Kits) are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes
decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown.
CUL4A played an oncogene (zeige RAB1A ELISA Kits) role through ZEB1 (zeige ZEB1 ELISA Kits) in IL-6 (zeige IL6 ELISA Kits)-induced colorectal carcinoma progression.
Overexpression of miR (zeige MLXIP ELISA Kits)-494 inhibited proliferation, migration, invasion and EMT (zeige ITK ELISA Kits) of ovarian cancer cells by directly suppressing CUL4A expression. Therefore, our findings indicate that miR (zeige MLXIP ELISA Kits)-494/CUL4A axis is important in the control of ovarian cancer tumorigenesis.
CUL4A sensitizes colorectal cancer cells to cisplatin induced cell death.
Elevated expression of CUL4A is positively correlated with distant metastases.
Increased CUL4A expression is associated with osteosarcoma.
Findings indicate the importance of a microRNAs miR (zeige MLXIP ELISA Kits)-9/137-CUL4A-Hippo signaling axis in gastric cancer (GC), and suggest new therapeutic targets for future treatment of GC.
These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.
CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.
Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.
this study revealed an indispensable role for Cul4a during male germ cell meiosis.
The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (zeige CUL4B ELISA Kits) gene is silenced due to meiotic sex chromosome inactivation.
CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.
Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.
a Cul4A ubiquitin ligase (zeige RNF123 ELISA Kits) positively regulates proliferation by targeting p27 (zeige CDKN1B ELISA Kits) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (zeige CDKN1B ELISA Kits) to accumulate and signal cell cycle exit
Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity
Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009