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CTBP2 produces alternative transcripts encoding two distinct proteins. Zusätzlich bieten wir Ihnen CTBP2 Antikörper (85) und CTBP2 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human CTBP2 Protein expressed in HEK-293 Cells - ABIN2712602
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
This Gene-based tests suggest evidence of association with related genes, ZEB2, RND3 (zeige RND3 Proteine), MCTP1, CTBP2, and beta EEG
Our results indicated that CCNH (zeige CCNH Proteine)/CDK7 (zeige CDK7 Proteine)-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
Releasing the key adipogenic regulator C/EBPalpha (zeige CEBPA Proteine) from CtBP2 binding.
Enhanced CtBP2expression promoted HCC (zeige FAM126A Proteine) xenograft growth and induced EMT (zeige ITK Proteine).
results show how CtBP2 contributes to prostate cancer progression by modulating AR and oncogenic signaling
High CTBP2 expression is associated with prostate cancer.
Overexpression of CtBP2 is associated with breast carcinoma.
CtBP2 might contribute to the progression of esophageal squamous cell carcinoma through a negative transcriptional regulation of p16(INK4A).
CtBP2 is over-expressed in prostate cancer.CtBP2 promotes prostate cancer cell proliferation through c-Myc (zeige MYC Proteine) signaling.
Crystal structures of human CtBP1 (zeige CTBP1 Proteine) and CtBP2 in complex with 4-Methylthio 2-oxobutyric acid and NAD.
studies revealed a new epigenetic pathway in the control of IL-2 (zeige IL2 Proteine) production in systemic lupus erythematosus whereby low levels of miR (zeige MLXIP Proteine)-200a-3p accumulate the binding of the ZEB1-CtBP2 complex to the IL-2 (zeige IL2 Proteine) promoter and suppress IL-2 (zeige IL2 Proteine) production
Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2 (zeige CA2 Proteine)+) channels
Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs (zeige NR2E3 Proteine) that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment.
Phosphorylation of KLF3 (zeige KLF3 Proteine) and CtBP2 by HIPK2 (zeige HIPK2 Proteine) strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (zeige KLF3 Proteine).
propose that Zscan4 (zeige ZSCAN4 Proteine) may regulate gene transcription in mouse ES cells through interaction with LSD1 (zeige KDM1A Proteine) and CtBP2
RIBEYE(B) interacts with ArfGAP3 (zeige ARFGAP3 Proteine) in vivo and in vitro.
CTBP2 is indispensable to create a chromatin environment conducive for RAR (zeige RARA Proteine)/RXR-mediated transcription by recruiting the histone acetyltransferase p300 (zeige EP300 Proteine).
Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.
Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors
Mice harboring various combinations of Ctbp1 (zeige CTBP1 Proteine) and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes
In photoreceptor cells, RIBEYE and RIM2 (zeige RIMS2 Proteine) are expressed along the synaptic ribbon.
Tcf-3 (zeige TCF3 Proteine) functions as a transcriptional regulator in the canonical Wnt (zeige WNT2 Proteine) signaling cascade and can repress or activate downstream target genes. The tcf-3 (zeige TCF3 Proteine) promoter was analyzed during early development of Xenopus.
Together, these results demonstrate that signaling through Tcf (zeige HNF4A Proteine) and Vent binding sites regulates transcription of geminin (zeige GMNN Proteine) in prospective neurectoderm during gastrulation
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3\; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
C-terminal binding protein 2
, C-terminal-binding protein 2-like
, C-terminal-binding protein 2
, gene trap ROSA b-geo 6
, ribeye a
, C-terminal-binding protein B
, TCF-3 corepressor CtBP
, Tcf-3 co-repressor CtBP