anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antikörper

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CBFA2T3 12398 O54972
CBFA2T3 863 O75081
CBFA2T3 361431  
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antikörper auf antikoerper-online.de

Showing 10 out of 30 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-CBFA2T3 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MTG16 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Meerschweinchen Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert WB <b>WB Suggested Anti-CBFA2T3 Antibody Titration: </b>2.5ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-CBFA2T3 <br /> Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Jurkat cell lysate <br /> CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
Details
Human Kaninchen Unkonjugiert IHC (p), ELISA 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
565,71 €
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
459,65 €
Details
Huhn Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
374,52 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC   100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Immunohistochemistry-Paraffin: CBFA2T3 Antibody  - Immunohistochemical staining of human tonsil shows strong nuclear positivity in germinal and non-germinal center cells. Western Blot: CBFA2T3 Antibody  - Western blot analysis in human cell line RT-4 and human cell line U-251 MG. 100 μL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details

CBFA2T3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine) , ,


Human , , ,
,

Rat (Rattus)


Weitere Antikörper gegen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Interaktionspartner

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaktionspartner

  1. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.

  2. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.

  3. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.

  4. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.

  5. Data suggest that MTG16 interfaces with critical components of the Notch (zeige NOTCH1 Antikörper) transcription complex to affect Notch (zeige NOTCH1 Antikörper)-dependent lineage allocation in hematopoiesis.

  6. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation

  7. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.

  8. MTG8/ETO (zeige RUNX1T1 Antikörper) and Mtg16 (also known as ETO2) associated with TCF4 (zeige TCF4 Antikörper)

  9. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 (zeige GATA1 Antikörper) and SCL (zeige TAL1 Antikörper).

  10. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia (zeige BCL11A Antikörper), is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaktionspartner

  1. Analysis of chromatin immunoprecipitation sequencing data sets for MTGR1 (zeige CBFA2T2 Antikörper) and MTG16 targets indicated that MTGR1 (zeige CBFA2T2 Antikörper) can regulate Wnt (zeige WNT2 Antikörper) and Notch (zeige NOTCH1 Antikörper) signaling.

  2. CBFA2T3 expression is regulated by Med19 (zeige MED19 Antikörper) in breast cancer cells.

  3. specific interference with ETO2-GLIS2 (zeige GLIS2 Antikörper) oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.

  4. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.

  5. ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.

  6. MTG16 co-repressor promotes degradation of HIF1alpha (zeige HIF1A Antikörper) in lymphoblasts.

  7. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (zeige CREBBP Antikörper), CBFA2T3, AMOTL1 (zeige AMOTL1 Antikörper), FAT4 (zeige FAT4 Antikörper), FBXO11 (zeige FBXO11 Antikörper), PLA2G4D, TRRAP (zeige TRRAP Antikörper) and USH2A (zeige USH2A Antikörper).

  8. Findings are unprecedented and indicate that the DHH (zeige DHH Antikörper)-RHEBL1 (zeige RHEBL1 Antikörper) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2 (zeige GLIS2 Antikörper)-positive childhood AML (zeige RUNX1 Antikörper).

  9. Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.

  10. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso (zeige ZBTB33 Antikörper) binding to its binding site on DNA, establishing MTG16-Kaiso (zeige ZBTB33 Antikörper) binding as functionally relevant in Kaiso (zeige ZBTB33 Antikörper)-dependent transcriptional repression

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antigen-Profil

Protein Überblick

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Genbezeichner und Symbole assoziert mit CBFA2T3

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3) Antikörper
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3) Antikörper
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (Cbfa2t3) Antikörper
  • A630044F12Rik Antikörper
  • AI465270 Antikörper
  • AW229127 Antikörper
  • Cbfa2t3h Antikörper
  • ETO-2 Antikörper
  • ETO2 Antikörper
  • MTG16 Antikörper
  • MTG16a Antikörper
  • MTG16b Antikörper
  • MTGR2 Antikörper
  • ZMYND4 Antikörper

Bezeichner auf Proteinebene für CBFA2T3

ETO/MTG8-related protein ETO-2 , MTG8-related protein 2 , core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog , eight twenty one protein 2 , myeloid translocation gene-related protein 2 , protein CBFA2T3 , protein ETO-2 , MTG8-related gene 2 , myeloid translocation gene 8 and 16b , myeloid translocation gene on chromosome 16 protein , zinc finger MYND domain-containing protein 4 , translocated to, 3

GENE ID SPEZIES
12398 Mus musculus
415846 Gallus gallus
863 Homo sapiens
361431 Rattus norvegicus
Ausgewählte Anbieter für anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antikörper
Haben Sie etwas anderes gesucht?