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In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. Zusätzlich bieten wir Ihnen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antikörper (88) und viele weitere Produktgruppen zu diesem Protein an.
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This repressive function is mediated through an ETO (zeige RUNX1T1 Proteine)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (zeige PRDM14 Proteine) and co-occupies its genomic targets in mouse embryonic stem cells.
Cbfa2t2(-/-) mice display severe defects in pri (zeige PRDM14 Proteine)mordial germ cell maturation and epigenetic reprogramming
MTGR1 is required for tumorigenesis in the murine AOM (zeige COL2A1 Proteine)/DSS (zeige PMP22 Proteine) colitis-associated carcinoma model.
Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.
Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.
c-Myc (zeige MYC Proteine), a transcriptional target of the Wnt (zeige WNT2 Proteine) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (zeige RAB1A Proteine)
Eto2 (zeige CBFA2T3 Proteine) and Mtgr1 as authentic interaction partners of Tal1 (zeige TAL1 Proteine) and suggest they act as heteromeric corepressors of this bHLH transcription factor (zeige MSGN1 Proteine) during erythroid differentiation.
in human colorectal cancer (CRC (zeige CALR Proteine)) samples MTGR1 was downregulated at both the transcript and protein level. Overall data indicates that MTGR1 has a context-dependent effect on intestinal tumorigenesis.
CBFA2T2 forms a biochemical complex with PRDM14 (zeige PRDM14 Proteine), a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 (zeige PRDM14 Proteine) and OCT4 (zeige POU5F1 Proteine) are stabilized on chromatin
The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.
report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112
ETO (zeige RUNX1T1 Proteine) family member-mediated oligomerization and repression can be distinct events and that interaction between ETO (zeige RUNX1T1 Proteine) family members and hSIN3B or N-CoR (zeige NCOR1 Proteine) may not necessarily strengthen transcriptional repression.
These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
translocated to, 2
, myeloid translocation gene-related protein 1
, protein CBFA2T2
, CBFA2T2 identified gene homolog
, MTG8-like protein
, MTG8-related protein 1
, core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog
, ETO homolog on chromosome 20
, ETO homologous on chromosome 20
, myeloid translocation-related protein 1
, a subunit 2; translocated to, 2
, expressed during neurogenesis