anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antikörper

In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. Zusätzlich bieten wir Ihnen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CBFA2T2 296293  
CBFA2T2 12396 O70374
CBFA2T2 9139 O43439
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Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antikörper auf antikoerper-online.de

Showing 10 out of 88 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB <b>WB Suggested Anti-CBFA2T2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-CBFA2T2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: HepG2 cell lysate <br /> CBFA2T2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Human Kaninchen Unkonjugiert EIA, WB   0.4 mL Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Hamster Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of MTGR1 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of MTGR1 expression in Jurkat (A), HepG2 (B), mouse testis (C), mouse kidney (D), rat brain (E) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Human Kaninchen Unkonjugiert ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2, antibody at 1:200 dilution. 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert IF, WB Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly.Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly.Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly. CBFA2T2 Antibody (N-term)  western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CBFA2T2 antibody detected the CBFA2T2 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details

CBFA2T2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Interaktionspartner

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Interaktionspartner

  1. This repressive function is mediated through an ETO (zeige RUNX1T1 Antikörper)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (zeige PRDM14 Antikörper) and co-occupies its genomic targets in mouse embryonic stem cells.

  2. Cbfa2t2(-/-) mice display severe defects in pri (zeige PRDM14 Antikörper)mordial germ cell maturation and epigenetic reprogramming

  3. MTGR1 is required for tumorigenesis in the murine AOM (zeige COL2A1 Antikörper)/DSS (zeige PMP22 Antikörper) colitis-associated carcinoma model.

  4. Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

  5. Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.

  6. c-Myc (zeige MYC Antikörper), a transcriptional target of the Wnt (zeige WNT2 Antikörper) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (zeige RAB1A Antikörper)

  7. Eto2 (zeige CBFA2T3 Antikörper) and Mtgr1 as authentic interaction partners of Tal1 (zeige TAL1 Antikörper) and suggest they act as heteromeric corepressors of this bHLH transcription factor (zeige MSGN1 Antikörper) during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Interaktionspartner

  1. in human colorectal cancer (CRC (zeige CALR Antikörper)) samples MTGR1 was downregulated at both the transcript and protein level. Overall data indicates that MTGR1 has a context-dependent effect on intestinal tumorigenesis.

  2. CBFA2T2 forms a biochemical complex with PRDM14 (zeige PRDM14 Antikörper), a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 (zeige PRDM14 Antikörper) and OCT4 (zeige POU5F1 Antikörper) are stabilized on chromatin

  3. The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.

  4. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112

  5. ETO (zeige RUNX1T1 Antikörper) family member-mediated oligomerization and repression can be distinct events and that interaction between ETO (zeige RUNX1T1 Antikörper) family members and hSIN3B or N-CoR (zeige NCOR1 Antikörper) may not necessarily strengthen transcriptional repression.

  6. These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antigen-Profil

Protein Überblick

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Genbezeichner und Symbole assoziert mit CBFA2T2

  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (Cbfa2t2) Antikörper
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2) Antikörper
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) Antikörper
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (cbfa2t2) Antikörper
  • A430091M07 Antikörper
  • C330013D05Rik Antikörper
  • cbfa2t2-a Antikörper
  • Cbfa2t2h Antikörper
  • EHT Antikörper
  • MTGR1 Antikörper
  • p85 Antikörper
  • XETOR Antikörper
  • ZMYND3 Antikörper

Bezeichner auf Proteinebene für CBFA2T2

translocated to, 2 , myeloid translocation gene-related protein 1 , protein CBFA2T2 , CBFA2T2 identified gene homolog , MTG8-like protein , MTG8-related protein 1 , core-binding factor runt domain alpha subunit 2 translocated to 2 homolog , core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog , ETO homolog on chromosome 20 , ETO homologous on chromosome 20 , myeloid translocation-related protein 1 , a subunit 2; translocated to, 2 , expressed during neurogenesis

GENE ID SPEZIES
296293 Rattus norvegicus
419155 Gallus gallus
12396 Mus musculus
9139 Homo sapiens
379213 Xenopus laevis
Ausgewählte Anbieter für anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antikörper
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