Connector Enhancer of Kinase Suppressor of Ras 1 Proteine (CNKSR1)

CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. Zusätzlich bieten wir Ihnen Connector Enhancer of Kinase Suppressor of Ras 1 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CNKSR1 10256 Q969H4
Maus CNKSR1 CNKSR1 194231  
Ratte CNKSR1 CNKSR1 298545  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details

CNKSR1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Interaktionspartnern

Human Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Interaktionspartner

  1. The findings reveal SAM (zeige TTN Proteine) domain-dependent oligomerization by AKT (zeige AKT1 Proteine) as a switch for CNK1 activation.

  2. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.

  3. CNK1 mediates ephrinB1 (zeige EFNB1 Proteine) signaling that promotes cell migration through RhoA (zeige RHOA Proteine) and JNK (zeige MAPK8 Proteine) activity.

  4. Studies indicate that CNK1-driven proliferation relies on Akt (zeige AKT1 Proteine)-dependent phosphorylation and inactivation of FoxO (zeige FOXO3 Proteine) proteins.

  5. These findings identify CNK1 as a new positive regulator of insulin (zeige INS Proteine) signaling.

  6. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.

  7. CNK1 promotes oncogenic signalling through Akt (zeige AKT1 Proteine) in breast cancer cell lines and tumours.

  8. hCNK1 associates with Rhophilin (zeige RHPN1 Proteine) and RalGDS (zeige RALGDS Proteine), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (zeige HOMER1 Proteine) to mediate cross talk between the two pathways

  9. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras.

  10. CNK1 couples a subset of Rho exchange factors to activation of the JNK (zeige MAPK8 Proteine) MAP kinase (zeige MAPK1 Proteine) pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho.

Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Protein Überblick

Protein Überblick

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.

Genbezeichner und Symbole assoziert mit CNKSR1

  • connector enhancer of kinase suppressor of Ras 1 (cnksr1)
  • connector enhancer of kinase suppressor of Ras 1 (CNKSR1)
  • connector enhancer of kinase suppressor of Ras 1 L homeolog (cnksr1.L)
  • connector enhancer of kinase suppressor of Ras 1 (Cnksr1)
  • BC037758 Protein
  • CNK Protein
  • CNK1 Protein
  • CNKSR1 Protein
  • KSR Protein
  • zgc:77200 Protein

Bezeichner auf Proteinebene für CNKSR1

connector enhancer of kinase suppressor of ras 1 , connector enhancer of kinase suppressor of Ras 1 , connector enhancer of kinase suppressor of ras 1-like , CNK homolog protein 1 , connector enhancer of KSR 1 , hCNK1

GENE ID SPEZIES
402957 Danio rerio
469241 Pan troglodytes
100015613 Monodelphis domestica
100144653 Xenopus (Silurana) tropicalis
100158310 Xenopus laevis
100462050 Pongo abelii
100476443 Ailuropoda melanoleuca
10256 Homo sapiens
487359 Canis lupus familiaris
100624309 Sus scrofa
194231 Mus musculus
298545 Rattus norvegicus
617552 Bos taurus
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