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CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. Zusätzlich bieten wir Ihnen Connector Enhancer of Kinase Suppressor of Ras 1 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.
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tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.
CNK1 mediates ephrinB1 (zeige EFNB1 Proteine) signaling that promotes cell migration through RhoA (zeige RHOA Proteine) and JNK (zeige MAPK8 Proteine) activity.
Studies indicate that CNK1-driven proliferation relies on Akt (zeige AKT1 Proteine)-dependent phosphorylation and inactivation of FoxO (zeige FOXO3 Proteine) proteins.
These findings identify CNK1 as a new positive regulator of insulin (zeige INS Proteine) signaling.
Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.
CNK1 promotes oncogenic signalling through Akt (zeige AKT1 Proteine) in breast cancer cell lines and tumours.
hCNK1 associates with Rhophilin (zeige RHPN1 Proteine) and RalGDS (zeige RALGDS Proteine), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (zeige HOMER1 Proteine) to mediate cross talk between the two pathways
Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras.
CNK1 couples a subset of Rho exchange factors to activation of the JNK (zeige MAPK8 Proteine) MAP kinase (zeige MAPK1 Proteine) pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho.
CNK1 allows cross-talk between Src (zeige SRC Proteine) and Raf-1 (zeige RAF1 Proteine) and is essential for the full activation of Raf-1 (zeige RAF1 Proteine)
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
connector enhancer of kinase suppressor of ras 1
, connector enhancer of kinase suppressor of Ras 1
, connector enhancer of kinase suppressor of ras 1-like
, CNK homolog protein 1
, connector enhancer of KSR 1