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The protein encoded by COG4 is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Zusätzlich bieten wir Ihnen COG4 Antikörper (25) und viele weitere Produktgruppen zu diesem Protein an.
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A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II.
Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG (zeige TG Proteine)) tethering complex; Sly1-COG (zeige TG Proteine) interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 (zeige STX5 Proteine) through a different binding site.
The 1.9 A crystal structure of a Cog4 C-terminal fragment, was determined. Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4's small C-terminal domain.
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.
component of oligomeric golgi complex 4
, Conserved oligomeric Golgi complex subunit 4
, COG complex subunit 4
, complexed with Dor1p
, conserved oligomeric Golgi complex protein 4
, conserved oligomeric Golgi complex subunit 4