Collagen, Type X, alpha 1 Proteine (COL10A1)

COL10A1 encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Zusätzlich bieten wir Ihnen Collagen, Type X, alpha 1 Kits (19) und Collagen, Type X, alpha 1 Antikörper (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
COL10A1 12813 Q05306
COL10A1 1300 Q03692
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Showing 2 out of 2 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details

COL10A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human

Weitere Proteine zu Collagen, Type X, alpha 1 (COL10A1) Interaktionspartnern

Mouse (Murine) Collagen, Type X, alpha 1 (COL10A1) Interaktionspartner

  1. In a model of instability-induced osteoarthritis, Col (zeige HDAC1 Proteine) X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1 (zeige OLR1 Proteine)(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1 (zeige OLR1 Proteine)(-)/(-) mice.

  2. Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.

  3. These data support a Cox-2-containing, Runx2 (zeige RUNX2 Proteine)-centered Col10a1 regulatory mechanism, during chondrocyte hypertrophic differentiation.

  4. Data indicate Indian hedgehog (Ihh (zeige IHH Proteine)) induces collagen type X COL10A1 expression and promotes its transcription through Runx2 (zeige RUNX2 Proteine)/Smad1 (zeige SMAD1 Proteine) interactions on a specific promoter region.

  5. these results show that increased Col10a1 expression in Phex (zeige PHEX Proteine)-deficient osteoblasts is not a major cause of the XLHR phenotype, which was an important issue to address based on the previous findings

  6. Downregulation of carbonic anhydrase IX (zeige CA9 Proteine) promotes Col10a1 expression in chondrocytes.

  7. Runx2 (zeige RUNX2 Proteine) directly interacts with murine Col10a1 cis (zeige CISH Proteine)-enhancer.

  8. SOX9 (zeige SOX9 Proteine) directly represses Col10a1 expression in immature/proliferating chondrocytes of the growth plate

  9. Studies indicate that Col10a1 is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population.

  10. cartilaginous regeneration is due to the expression of chondrogenic factors, such as Sox 9 (zeige SOX9 Proteine) and type II and X collagens

Human Collagen, Type X, alpha 1 (COL10A1) Interaktionspartner

  1. increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2 (zeige ERBB2 Proteine)+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment

  2. a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia

  3. COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population

  4. The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.

  5. Yiqi Huayu Bushen Recipe increased the expression of aggrecan (zeige ACAN Proteine), decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs.

  6. Genetic variation near FRK (zeige FRK Proteine)/COL10A1 and VEGFA (zeige VEGFA Proteine) are associated with advanced age-related macular degeneration.

  7. MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available

  8. a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia type Schmid

  9. The effect of parathyroid hormone on expression of COL10 and COL2 in mesenchymal stem cells from osteoarthritic patients and analyzed the potential mechanisms related to its effect, was investigated.

  10. These results indicate that nitrogen-rich plasma polymerized surfaces inhibit COL10A1 expression via the suppression of COX-1.

Cow (Bovine) Collagen, Type X, alpha 1 (COL10A1) Interaktionspartner

  1. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.

  2. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation

Collagen, Type X, alpha 1 (COL10A1) Protein Überblick

Protein Überblick

This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

Genbezeichner und Symbole assoziert mit COL10A1

  • collagen, type X, alpha 1 (Col10a1)
  • collagen type X alpha 1 chain (COL10A1)
  • collagen, type X, alpha 1 (COL10A1)
  • Col10 Protein
  • Col10a-1 Protein

Bezeichner auf Proteinebene für COL10A1

collagen alpha-1(X) chain , procollagen, type X, alpha 1 , Schmid metaphyseal chondrodysplasia , collagen X, alpha-1 polypeptide , collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia) , collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) , type X collagen alpha 1

GENE ID SPEZIES
12813 Mus musculus
1300 Homo sapiens
282416 Bos taurus
100858979 Gallus gallus
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