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CCDC6 encodes a coiled-coil domain-containing protein. Zusätzlich bieten wir Ihnen CCDC6 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CCDC6 Primary Antibody für WB - ABIN1881146
Leone, Mansueto, Pierantoni, Tornincasa, Merolla, Cerrato, Santoro, Grieco, Scaloni, Celetti, Fusco: CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. in Oncogene 2010
Show all 5 Pubmed References
FGFR (zeige FGFR2 Antikörper) inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2 (zeige FGFR2 Antikörper)-CCDC6 fusions.
Our findings nevertheless suggest that CCDC6-RET (zeige RET Antikörper) fusions identified by multiplex testing are potential targets for nintedanib therapy.
we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications
Results show that RNA-binding protein EWS (zeige EWSR1 Antikörper) binds and regulates CCDC6 expression at RNA and protein levels.
CCDC6 levels provide valuable insight for OS.
the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.
Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.
CCDC6 is associated with cAMP signaling by fine regulating CREB1 (zeige CREB1 Antikörper) transcriptional activity in normal and transformed thyroid cells.
CCDC6-RET (zeige RET Antikörper) fusion is associated with lung adenocarcinoma.
It was shown that FBXW7 (zeige FBXW7 Antikörper) interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7 (zeige FBXW7 Antikörper)-mediated CCDC6 degradation was impaired in response to DNA damage.
Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 (zeige CREB1 Antikörper) activity and an increased expression of the CREB-1 (zeige CREB1 Antikörper) regulated genes.
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.
coiled-coil domain-containing protein 6
, coiled-coil domain containing 6
, papillary thyroid carcinoma-encoded protein