Chromosome 19 Open Reading Frame 40 (C19ORF40) ELISA Kits

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen Chromosome 19 Open Reading Frame 40 Antikörper (8) und Chromosome 19 Open Reading Frame 40 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human C19ORF40 C19ORF40 91442 Q9BTP7
Anti-Maus C19ORF40 C19ORF40 101831 Q8BHL6
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Weitere ELISA Kits für Chromosome 19 Open Reading Frame 40 Interaktionspartner

Human Chromosome 19 Open Reading Frame 40 (C19ORF40) Interaktionspartner

  1. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM (zeige FANCM ELISA Kits)/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.

  2. Crystal structure of the FANCM (zeige FANCM ELISA Kits)-FAAP24 complex.

  3. Results show that the first HhH (zeige SLC25A15 ELISA Kits) motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM (zeige FANCM ELISA Kits)-FAAP24 to chromatin.

  4. FANCM (zeige FANCM ELISA Kits) and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.

  5. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.

  6. FAAP24 targets FANCM (zeige FANCM ELISA Kits) to structures that mimic intermediates formed during the replication/repair of damaged DNA.

  7. FANCM (zeige FANCM ELISA Kits) is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM (zeige FANCM ELISA Kits)/FAAP24 interaction is essential for this chromatin-loading activity

  8. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM (zeige FANCM ELISA Kits).

  9. DNA damage recognition and remodeling activities of FANCM (zeige FANCM ELISA Kits) and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia (zeige PALB2 ELISA Kits).

Chromosome 19 Open Reading Frame 40 (C19ORF40) Antigen-Profil

Beschreibung des Gens

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007

Genbezeichner und Symbole assoziert mit C19ORF40

  • Fanconi anemia core complex associated protein 24 (FAAP24) Antikörper
  • Fanconi anemia core complex associated protein 24 (Faap24) Antikörper
  • AW124591 Antikörper
  • AW538696 Antikörper
  • Faap24 Antikörper

Bezeichner auf Proteinebene für C19ORF40

Fanconi anemia-associated protein of 24 kDa , Fanconi anemia-associated protein, 24 kDa

GENE ID SPEZIES
510793 Bos taurus
91442 Homo sapiens
101831 Mus musculus
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