Chromosome 12 Open Reading Frame 52 Proteine (C12orf52)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Zusätzlich bieten wir Ihnen Chromosome 12 Open Reading Frame 52 Antikörper (27) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
C12orf52 84934 Q96K30
Maus C12orf52 C12orf52 100764 Q9D1H0
C12orf52 288683 Q2KJ10
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.482,86 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.538,73 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.571,90 €
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Hefe REACT_Panda His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.571,90 €
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C12orf52 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Rat (Rattus)

Weitere Proteine zu Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartnern

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (zeige RBPJ Proteine)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. structural and biophysical studies demonstrate that RITA (zeige ZNF331 Proteine) binds RBP-J (zeige RBPJ Proteine) similarly to the RAM (zeige RAB27A Proteine) (RBP-J (zeige RBPJ Proteine)-associated molecule) domain of Notch (zeige NOTCH1 Proteine), our biochemical and cellular assays suggest that RITA (zeige ZNF331 Proteine) interacts with additional regions in RBP-J (zeige RBPJ Proteine).

  2. RITA (zeige ZNF331 Proteine) overexpression increased expression of p53 (zeige TP53 Proteine) and Fbxw7 (zeige FBXW7 Proteine) and downregulated expression of cyclin D1 (zeige CCND1 Proteine), cyclin E (zeige CCNE1 Proteine), CDK2 (zeige CDK2 Proteine), Hes-1 and NF-kappaB (zeige NFKB1 Proteine) p65 (zeige GORASP1 Proteine). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA (zeige ZNF331 Proteine), binding to Drosophila Su(H (zeige RBPJ Proteine)) and tubulin (zeige TUBB Proteine), cannot influence the Notch (zeige NOTCH1 Proteine) signalling pathway in the fly

  4. RITA (zeige ZNF331 Proteine) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. structural and biophysical studies demonstrate that RITA binds RBP-J (zeige RBPJ Proteine) similarly to the RAM (zeige FAM103A1 Proteine) (RBP-J (zeige RBPJ Proteine)-associated molecule) domain of Notch (zeige NOTCH1 Proteine), our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J (zeige RBPJ Proteine).

Chromosome 12 Open Reading Frame 52 (C12orf52) Protein Überblick

Protein Überblick

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Genbezeichner und Symbole assoziert mit C12orf52

  • chromosome 12 open reading frame 52 (C12orf52)
  • chromosome 12 open reading frame 52 (c12orf52)
  • chromosome 17 open reading frame, human C12orf52 (C17H12orf52)
  • RIKEN cDNA 1110008J03 gene (1110008J03Rik)
  • similar to RIKEN cDNA 1110008J03 (RGD1306772)
  • AI853657 Protein
  • C12orf52 Protein
  • C86297 Protein
  • Rita Protein

Bezeichner auf Proteinebene für C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPEZIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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