Chromosome 12 Open Reading Frame 52 (C12orf52) ELISA Kits

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Zusätzlich bieten wir Ihnen Chromosome 12 Open Reading Frame 52 Antikörper (27) und Chromosome 12 Open Reading Frame 52 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human C12orf52 C12orf52 84934 Q96K30
Anti-Maus C12orf52 C12orf52 100764 Q9D1H0
Anti-Ratte C12orf52 C12orf52 288683 Q2KJ10
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Weitere ELISA Kits für Chromosome 12 Open Reading Frame 52 Interaktionspartner

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (zeige RBPJ ELISA Kits)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. structural and biophysical studies demonstrate that RITA (zeige ZNF331 ELISA Kits) binds RBP-J (zeige RBPJ ELISA Kits) similarly to the RAM (zeige RAB27A ELISA Kits) (RBP-J (zeige RBPJ ELISA Kits)-associated molecule) domain of Notch (zeige NOTCH1 ELISA Kits), our biochemical and cellular assays suggest that RITA (zeige ZNF331 ELISA Kits) interacts with additional regions in RBP-J (zeige RBPJ ELISA Kits).

  2. RITA (zeige ZNF331 ELISA Kits) overexpression increased expression of p53 (zeige TP53 ELISA Kits) and Fbxw7 (zeige FBXW7 ELISA Kits) and downregulated expression of cyclin D1 (zeige CCND1 ELISA Kits), cyclin E (zeige CCNE1 ELISA Kits), CDK2 (zeige CDK2 ELISA Kits), Hes-1 and NF-kappaB (zeige NFKB1 ELISA Kits) p65 (zeige GORASP1 ELISA Kits). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA (zeige ZNF331 ELISA Kits), binding to Drosophila Su(H (zeige RBPJ ELISA Kits)) and tubulin (zeige TUBB ELISA Kits), cannot influence the Notch (zeige NOTCH1 ELISA Kits) signalling pathway in the fly

  4. RITA (zeige ZNF331 ELISA Kits) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) Interaktionspartner

  1. structural and biophysical studies demonstrate that RITA binds RBP-J (zeige RBPJ ELISA Kits) similarly to the RAM (RBP-J (zeige RBPJ ELISA Kits)-associated molecule) domain of Notch (zeige NOTCH1 ELISA Kits), our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J (zeige RBPJ ELISA Kits).

Chromosome 12 Open Reading Frame 52 (C12orf52) Antigen-Profil

Beschreibung des Gens

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Genbezeichner und Symbole assoziert mit C12orf52

  • chromosome 12 open reading frame 52 (C12orf52) Antikörper
  • chromosome 12 open reading frame 52 (c12orf52) Antikörper
  • chromosome 17 open reading frame, human C12orf52 (C17H12orf52) Antikörper
  • RIKEN cDNA 1110008J03 gene (1110008J03Rik) Antikörper
  • similar to RIKEN cDNA 1110008J03 (RGD1306772) Antikörper
  • AI853657 Antikörper
  • C12orf52 Antikörper
  • C86297 Antikörper
  • Rita Antikörper

Bezeichner auf Proteinebene für C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPEZIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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