anti-Chromosome 10 Open Reading Frame 2 (C10ORF2) Antikörper

C10ORF2 encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. Zusätzlich bieten wir Ihnen Chromosome 10 Open Reading Frame 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
C10ORF2 56652 Q96RR1
C10ORF2 309441  
C10ORF2 226153 Q8CIW5
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Top anti-Chromosome 10 Open Reading Frame 2 Antikörper auf antikoerper-online.de

Showing 10 out of 55 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-PEO1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB C10orf2 Antibody (C-term)  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow). C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. C10orf2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35µg/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$323.13
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Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.13
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.13
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded mouse testis tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-Twinkle Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details

C10ORF2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Chromosome 10 Open Reading Frame 2 Antikörper

  1. Cow (Bovine) Polyclonal C10ORF2 Primary Antibody für WB - ABIN2775251 : Farge, Holmlund, Khvorostova, Rofougaran, Hofer, Falkenberg: The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities. in Nucleic acids research 2008 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen Chromosome 10 Open Reading Frame 2 Interaktionspartner

Human Chromosome 10 Open Reading Frame 2 (C10ORF2) Interaktionspartner

  1. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4 (zeige HSD17B4 Antikörper), LARS2 (zeige LARS2 Antikörper), CLPP (zeige CLPP Antikörper) and C10orf2

  2. It has been demonstrated that MTERF1 (zeige MTERF Antikörper) arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 (zeige MTERF Antikörper) acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE.

  3. sequencing coding regions of C10orf2 revealed three variants in three different patients, of which two were novel (c.1964G>A/p.G655D; c.204G>A/p.G68G) variants and one was reported (c.1052A>G/p. N351S).

  4. We identified a missense mutation in c10orf2 in an Iranian family with an association to progressive external ophthalmoplegia, myopathy, dysphagia, dysphonia, and behavior change. Early death was also a novel feature in affected family members.

  5. An electron microscopy model of Twinkle reveals a hexameric two-layered ring comprising the zinc-binding domain and RNA polymerase domain in one layer and the RecA-like hexamerization C-terminal domain in another.

  6. Identified compound heterozygous mutations of the C10orf2 gene as the cause of infantile-onset spinocerebellar ataxia with sensorimotor polyneuropathy and myopathy.

  7. The mitochondrial replicative helicase Twinkle inefficiently unwinds well characterized intermolecular and intramolecular G-quadruplex DNA substrates, as well as a unimolecular G4 substrate.

  8. 16-year follow-up of autosomal dominant progressive external ophthalmoplegia (adPEO) due to the p.R357P gene mutation in PEO1; adPEO due to this mutation is a late-onset ocular myopathy beginning with ptosis and progressing slowly; ophthalmoparesis, if present, is mild

  9. Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.

  10. analysis did not reveal disease causing POLG (zeige POLG Antikörper) or PEO1 mutations in patients with atypical parkinsonism

Mouse (Murine) Chromosome 10 Open Reading Frame 2 (C10ORF2) Interaktionspartner

  1. study describes findings in a family with late onset parkinsonism and progressive external ophthalmoplegia, with mutation of G1750A in the exon 1 of PEO1 gene

  2. TWINKLE is essential for nascent H-strand synthesis in the D-loop, thus showing that there is no separate DNA helicase responsible for replication of this region.

Chromosome 10 Open Reading Frame 2 (C10ORF2) Antigen-Profil

Protein Überblick

This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit C10ORF2

  • twinkle mtDNA helicase L homeolog (twnk.L) Antikörper
  • twinkle mtDNA helicase (TWNK) Antikörper
  • twinkle mtDNA helicase (Twnk) Antikörper
  • ATXN8 Antikörper
  • C6H10orf2 Antikörper
  • D19Ertd626e Antikörper
  • IOSCA Antikörper
  • MTDPS7 Antikörper
  • PEO Antikörper
  • PEO1 Antikörper
  • PEOA3 Antikörper
  • SANDO Antikörper
  • SCA8 Antikörper
  • Twinl Antikörper

Bezeichner auf Proteinebene für C10ORF2

uncharacterized protein LOC414487 , twinkle protein, mitochondrial , T7 gp4-like protein with intramitochondrial nucleoid localization , T7 helicase-related protein with intramitochondrial nucleoid localization , T7-like mitochondrial DNA helicase , ataxin 8 , mitochondrial twinkle protein , progressive external ophthalmoplegia 1 protein , progressive external ophthalmoplegia 1 , progressive external ophthalmoplegia 1 homolog , progressive external ophthalmoplegia 1 protein homolog

GENE ID SPEZIES
414487 Xenopus laevis
710958 Macaca mulatta
56652 Homo sapiens
486845 Canis lupus familiaris
309441 Rattus norvegicus
425626 Gallus gallus
226153 Mus musculus
Ausgewählte Anbieter für anti-Chromosome 10 Open Reading Frame 2 (C10ORF2) Antikörper
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