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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Zusätzlich bieten wir Ihnen CBX8 Antikörper (154) und viele weitere Produktgruppen zu diesem Protein an.
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Cbx8 associates with non-PRC1 (zeige PRC1 Proteine) complexes containing the H3K4 methyltransferase complex component WDR5 (zeige WDR5 Proteine), which together regulate Notch (zeige NOTCH1 Proteine) gene expression.
CBX8 plates roles in epigenetic regulation in DNA damage response.
Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.
CBX8 plays an essential role in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) transcriptional regulation and leukemogenesis.
Pcl2 (zeige MTF2 Proteine)-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.
Huntingtin (zeige HTT Proteine) is a novel stimulator of polycomb (zeige CBX2 Proteine) repressive complex 2.
The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 (zeige TP53 Proteine) pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.
CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1 (zeige PRC1 Proteine)-BCOR (zeige BCOR Proteine) complex at BCL6 (zeige BCL6 Proteine) binding sites to specifically silence genes in the germinal center and promote lymphomagenesis
IGF1 (zeige IGF1 Proteine) can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression
The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.
These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.
Low CBX8 expression was associated with distant metastasis in colorectal cancer.
CBX8 might emerge as an oncogene (zeige RAB1A Proteine) for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.
The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
Interaction with CBX8 precludes AF9 (zeige MLLT3 Proteine)-DOT1L (zeige DOT1L Proteine) binding.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 8
, chromobox protein homolog 8
, polycomb 3 homolog
, Pc class 3 homolog
, chromobox homolog 8 (Pc class homolog, Drosophila)
, polycomb 3
, rectachrome 1
, chromobox-like protein 8
, chromobox homolog 8 (Pc class homolog)
, chromobox homolog 8a