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Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Zusätzlich bieten wir Ihnen CBX5 Antikörper (271) und CBX5 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that SUMOylated heterochromatin protein 1-alpha (HP1alpha)alpha is a critical epigenetic-regulator of DNA-repair in breast cancer (BCa (zeige BLNK Proteine)) that could define chemotherapy responsiveness.
findings suggest that heterochromatin-mediated gene silencing may occur in part through sequestration of compacted chromatin in phase-separated HP1 (zeige DEFA1 Proteine) droplets, which are dissolved or formed by specific ligands on the basis of nuclear context
Data show that SALL4 (zeige SALL4 Proteine) promotes the expression of Glut1 (zeige SLC2A1 Proteine) and open chromatin through a HP1alpha-dependent mechanism.
Identify a nucleosome interaction module within KDM2A (zeige KDM2A Proteine) consisting of a CXXC type zinc finger, a PHD (zeige PDC Proteine) domain and a newly identified Heterochromatin Protein 1 (HP1 (zeige DEFA1 Proteine)) interaction motif that mediates direct binding between KDM2A (zeige KDM2A Proteine) and HP1 (zeige DEFA1 Proteine). This nucleosome interaction module enables KDM2A (zeige KDM2A Proteine) to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
These data suggests that up-regulated HP1A (zeige TFF1 Proteine) and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression.
Loss of HP1alpha and gamma isoforms inhibits the upregulation of Suv39h1 (zeige SUV39H1 Proteine) and H3K9me3 that is observed under stress conditions.
we showed the essential role of HP1 (zeige DEFA1 Proteine) in regulating HR through BRCA1/BARD1 (zeige BARD1 Proteine)-mediated accumulation of FANCJ and CtIP (zeige RBBP8 Proteine) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.
We demonstrate that an hnRNPA1 (zeige HNRNPA1 Proteine) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells
HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.
Jra recruits the HP1a (zeige TFF1 Proteine)/KDM4A (zeige KDM4A Proteine) complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation
HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.
demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin
the molecular behavior of HP1alpha throughout the cell cycle
There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (zeige Zmpste24 Proteine)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.
the TIF1beta (zeige TRIM28 Proteine)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.
HP1 mobility in apoptotic cells appeared to be unique.
Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.
Depletion of Senp7 (zeige SENP7 Proteine) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
The interplay between MU2 (zeige AP2M1 Proteine) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
KAP1 (zeige TRIM28 Proteine) and HP1 tether activation-induced cytidine deaminase (zeige AICDA Proteine) (AID) to H3K9me3 residues at the donor switch region, thus linking AID to epigenetic modifications during class switch recombination.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
HP1 alpha homolog
, HP1Hs alpha
, antigen p25
, chromobox homolog 5 (HP1 alpha homolog, Drosophila)
, chromobox protein homolog 5
, heterochromatin protein 1 homolog alpha
, heterochromatin protein 1-alpha
, chromobox-like protein 5
, chromobox-like protein 5 (HP1 alpha homolog, Drosophila)
, HP1 alpha
, chromobox homolog 5
, heterochromatin protein 1 alpha
, chromobox homolog 5 tv3