Chimerin 1 (CHN1) ELISA Kits

CHN1 encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus CHN1 CHN1 108699 Q91V57
Anti-Ratte CHN1 CHN1 84030 P30337
Anti-Human CHN1 CHN1 1123 P15882
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Weitere ELISA Kits für Chimerin 1 Interaktionspartner

Zebrafish Chimerin 1 (CHN1) Interaktionspartner

  1. These findings demonstrate that a correct level of alpha2-chimaerin signaling is required for key oculomotor axon guidance decisions, and provide a zebrafish model for Duane Retraction Syndrome.

Mouse (Murine) Chimerin 1 (CHN1) Interaktionspartner

  1. These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder

  2. This study showed that, in the mouse, hippocampal alpha2-chimaerin acts in the late postnatal stages (juvenile and adolescence) to establish both the baseline level of the dendritic spine morphology and normal contextual fear-learning ability in adulthood

  3. Developmental alpha2-chimaerin activity is important for adult cognition.

  4. Chimaerins are RhoGTPase-activating proteins that are EphA4 (zeige EPHA4 ELISA Kits) effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits.

  5. These findings establish a new alpha2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders.

  6. Chimaerin, one of the Rho GTPase (zeige RACGAP1 ELISA Kits) activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons.

  7. lpha1-chimaerin is an activity-regulated Rho GTPase (zeige RACGAP1 ELISA Kits) regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors

  8. Rac (zeige AKT1 ELISA Kits)-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 (zeige EFNB3 ELISA Kits) forward signaling

  9. Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4 (zeige EPHA4 ELISA Kits), which is essential for axon guidance decisions and neuronal circuit formation in vivo.

  10. These findings identify alpha2-chimaerin as an indispensable effector for EphA4 (zeige EPHA4 ELISA Kits) in cortical and spinal motor circuits.

Cow (Bovine) Chimerin 1 (CHN1) Interaktionspartner

  1. These data indicate that as a consequence of weaning, which causes physiological stress and alters hepatic metabolism, chemerin (zeige RARRES2 ELISA Kits) protein expression within the liver is downregulated, indicating that chemerin (zeige RARRES2 ELISA Kits) plays a role in the upregulation of hepatic expression via its inhibitory effect on hepatic gluconeogenesis.

  2. Association between a single nucleotide polymorphism in the bovine chemerin (zeige RARRES2 ELISA Kits) gene and carcass traits

Human Chimerin 1 (CHN1) Interaktionspartner

  1. These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder

  2. this study shows that serum chemerin (zeige RARRES2 ELISA Kits) is an independent risk factor of prognosis of non-small cell lung cancer patients

  3. reduced alpha1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process.

  4. The patients most similar belong to families with a small or absent cranial nerve VI and septo-optic hypoplasia who carry CHN1 mutations

  5. Analysis of the current pedigree expands the phenotypic spectrum of hyperactivating CHN1 mutations to include vertical strabismus (zeige VANGL2 ELISA Kits) and supraduction deficits in the absence of Duane retraction syndrome.

  6. Members of families segregating Duane retraction syndrome (DRS (zeige PNN ELISA Kits)) as an autosomal dominant trait should be screened for mutations in the CHN1 gene, enhancing genetic counseling and permitting earlier diagnosis.

  7. We found no evidence for a causative involvement of CHN1 mutations in congenital ocular motor anomalies different from autosomal dominant Duane's retraction syndrome

  8. study concludes that CHN1 mutations are not a major cause of Duane's retraction syndrome among individuals with sporadic disease

  9. we show that alpha-chimaerin is a Cdk5p35-binding protein; in transfected HeLa cells, Cdk5p35 and alpha-chimaerin displayed an overlapping distribution pattern

  10. These two pedigrees double the published pedigrees known to map to the DURS2 locus and can thus contribute toward the search for the DURS2 gene

Chimerin 1 (CHN1) Antigen-Profil

Beschreibung des Gens

This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit Chimerin 1 (CHN1) ELISA Kits

  • chimerin (chimaerin) 1 (chn1) Antikörper
  • chimerin 1 (chn1) Antikörper
  • chimerin (chimaerin) 1 (CHN1) Antikörper
  • chimerin (chimaerin) 1 (Chn1) Antikörper
  • chimerin 1 (CHN1) Antikörper
  • 0610007I19Rik Antikörper
  • 0710001E19Rik Antikörper
  • 1700112L09Rik Antikörper
  • 2900046J01Rik Antikörper
  • AI413815 Antikörper
  • ARHGAP2 Antikörper
  • chimaerin Antikörper
  • CHN Antikörper
  • DURS2 Antikörper
  • N-chimaerin Antikörper
  • NC Antikörper
  • RHOGAP2 Antikörper
  • wu:fr89a09 Antikörper
  • zgc:56160 Antikörper
  • zgc:92906 Antikörper

Bezeichner auf Proteinebene für Chimerin 1 (CHN1) ELISA Kits

N-chimaerin , alpha chimerin , z-chimaerin , chimerin (chimaerin) 1 , A-chimaerin , N-chimerin , NC , alpha-chimerin , alpha1 chimaerin , alpha2 chimaerin , alpha3-chimerin , chimaerin , rho GTPase-activating protein 2 , Rho GTPase-activating protein 2 , a2-chimaerin , chimaerin 1 , n-chimerin

GENE ID SPEZIES
406273 Danio rerio
380027 Xenopus laevis
429021 Gallus gallus
108699 Mus musculus
84030 Rattus norvegicus
508266 Bos taurus
478805 Canis lupus familiaris
1123 Homo sapiens
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