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CHMP4B encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. Zusätzlich bieten wir Ihnen CHMP4B Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.
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Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (zeige CHMP4A Proteine) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (zeige CHMP4A Proteine) = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1 (zeige BIN1 Proteine))
homologous domain of human Bro1 (zeige HMGCR Proteine) domain-containing proteins, Alix (zeige PDCD6IP Proteine) and Brox, binds CHMP4B (zeige CHMP4A Proteine) but not STAM2 (zeige STAM2 Proteine), despite their high structural similarity
The ESCRT-III subunit CHMP4B (zeige CHMP4A Proteine) is a key effector in abscission, whereas its paralogue, CHMP4C (zeige CHMP4C Proteine), is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge.
our results implied that CHMP4B (zeige CHMP4A Proteine) could be a promising prognostic biomarker as well as a potential therapeutic target of HCC (zeige FAM126A Proteine).
CHMP4B (zeige CHMP4A Proteine), through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin.
CHMP4B (zeige CHMP4A Proteine) interacts directly with CC2D1A (zeige CC2D1A Proteine) and CC2D1B (zeige CC2D1B Proteine) with nanomolar affinity by forming a 1:1 complex.
CC2D1A (zeige CC2D1A Proteine) interaction with CHMP4B (zeige CHMP4A Proteine)/4A blocks HIV-1 budding.
hSnf7-1 and hSnf7-2 are preferentially associated with CHMP2A (zeige CHMP2A Proteine) and CHMP2B (zeige CHMP2B Proteine), respectively, and regulate the turnover of distinct transmembrane cargos such as neurotransmitter receptors in human neurons.
CHMP4b (zeige CHMP4A Proteine) and Alix (zeige PDCD6IP Proteine) participate in formation of multivesicular bodies by cooperating with SKD1 (zeige vps4b Proteine)
ALIX (zeige PDCD6IP Proteine) can have a dramatic effect on HIV-1 release by binding at the CHMP4B (zeige CHMP4A Proteine) site; the ability to use ALIX (zeige PDCD6IP Proteine) may allow HIV-1 to replicate in cells that express only low levels of Tsg101 (zeige TSG101 Proteine)
CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin.
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
SNF7 homolog associated with Alix 1
, Snf7 homologue associated with Alix 1
, charged multivesicular body protein 4b
, chromatin modifying protein 4B
, chromatin-modifying protein 4b
, vacuolar protein sorting-associated protein 32-2
, vacuolar protein-sorting-associated protein 32-2