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Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. Zusätzlich bieten wir Ihnen Centromere Protein H Kits (18) und Centromere Protein H Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CENPH Primary Antibody für IHC, IHC (p) - ABIN4297684
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Cow (Bovine) Polyclonal CENPH Primary Antibody für WB - ABIN2787617
Liao, Zhang, Zhou, Zimonjic, Mani, Kaba, Gifford, Reinhardt, Popescu, Guo, Eaton, Lodish, Weinberg: Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. in Cancer research 2007
Show all 2 Pubmed References
Upregulation of centromere protein H is associated with progression of renal cell carcinoma (zeige MOK Antikörper)
propose that CSPP1 (zeige Cspp1 Antikörper) cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation
CENP-H was overexpressed in HCC (zeige FAM126A Antikörper), and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC (zeige FAM126A Antikörper).
CENP-H promotes the proliferation of human gastric cancer cells
High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin (zeige BIRC5 Antikörper) may mediate its procancer role.
Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage.
upregulated CENP-H and Ki67 (zeige MKI67 Antikörper) levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases
Sp1 (zeige PSG1 Antikörper) and Sp3 (zeige SP3 Antikörper) bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas.
CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers.
The CENP-H-I complex may function, in part, as a marker directing CENP-A (zeige CENPA Antikörper) deposition to centromeres.
A novel role of CenpH in regulating meiotic G2/M transition by acting via the APC (zeige APC Antikörper)/C(Cdh1 (zeige CDH1 Antikörper))-cyclin B1 (zeige CCNB1 Antikörper) pathway.
essential role of cenph in mitosis and embryonic development and its association with tumor development
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
, interphase centromere complex protein 35
, kinetochore protein CENP-H
, centromere autoantigen H
, centromere protein H