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Cdk5 and Abl Enzyme Substrate 1 Proteine (CABLES1)

CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. Zusätzlich bieten wir Ihnen Cdk5 and Abl Enzyme Substrate 1 Antikörper (25) und Cdk5 and Abl Enzyme Substrate 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CABLES1 91768 Q8TDN4
CABLES1 63955 Q9ESJ1
Ratte CABLES1 CABLES1 307585  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
218,90 €
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CABLES1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartnern

Zebrafish Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5 (zeige CDK5 Proteine)/p35 (zeige CDK5R1 Proteine) kinase pathway.

Human Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. Cables1/p21 (zeige CDKN1A Proteine) pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 (zeige CDKN1A Proteine) is probably one of several downstream effector molecules to mediate Cables1.

  2. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease

  3. the results suggest Cables1 as a novel p21 (zeige CDKN1A Proteine) regulator through maintaining p21 (zeige CDKN1A Proteine) stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21 (zeige CDKN1A Proteine).

  4. Results illuminated a dynamic regulatory system through which activated Akt (zeige AKT1 Proteine) and 14-3-3 (zeige YWHAQ Proteine) work directly together to neutralize a potent tumor suppressor function of Cables1.

  5. The results did not detect a significant association. It indicated that common genetic variations in CDK5 (zeige CDK5 Proteine) genes might not play a role in the genetic predisposition to autism.

  6. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing.

  7. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.

Mouse (Murine) Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. Loss of Cables1 enhances tumor progression in the Apc (zeige APC Proteine)(Min/+) mouse model and activates the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.

  2. Agenesis of the corpus callosum frequency in Cables1(+/TAS (zeige MAP3K4 Proteine)) mice was significantly lower than that in Cables1(-/TAS (zeige MAP3K4 Proteine)) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS (zeige MAP3K4 Proteine)).

  3. Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.

  4. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.

Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Protein Überblick

Protein Überblick

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CABLES1

  • Cdk5 and Abl enzyme substrate 1 (CABLES1)
  • Cdk5 and Abl enzyme substrate 1 (cables1)
  • Cdk5 and Abl enzyme substrate 1 (CpipJ_CPIJ019832)
  • CDK5 and Abl enzyme substrate 1 (Cables1)
  • Cdk5 and Abl enzyme substrate 1 (Cables1)
  • CABL1 Protein
  • Cables Protein
  • CABLES1 Protein
  • HsT2563 Protein
  • ik3-1 Protein
  • si:dkey-2p18.3 Protein

Bezeichner auf Proteinebene für CABLES1

Cdk5 and Abl enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1-like , interactor with CDK3 1 , cdk3-binding protein ik3-1 , interactor-1 with cdk3

GENE ID SPEZIES
455335 Pan troglodytes
100059359 Equus caballus
100126070 Danio rerio
100345850 Oryctolagus cuniculus
100479459 Ailuropoda melanoleuca
6054063 Culex quinquefasciatus
100562423 Anolis carolinensis
100603520 Nomascus leucogenys
91768 Homo sapiens
63955 Mus musculus
768914 Gallus gallus
100682687 Canis lupus familiaris
100526114 Sus scrofa
100138286 Bos taurus
307585 Rattus norvegicus
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