Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 Proteine (CACNA2D1)

CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Zusätzlich bieten wir Ihnen CACNA2D1 Antikörper (75) und CACNA2D1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CACNA2D1 781 P54289
CACNA2D1 12293 O08532
Ratte CACNA2D1 CACNA2D1 25399  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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CACNA2D1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine)
,

Weitere Proteine zu Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartnern

Human Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartner

  1. detected a joint effect of SNP and G x E interaction in BMP2 (zeige BMP2 Proteine) and CACNA2D1 for depressive state.

  2. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features.

  3. Compound mutation of CACNA2D1 and RANGRF (zeige RANGRF Proteine) genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy.

  4. High prevalence of CACNA2D1, SCN5A (zeige SCN5A Proteine), and CACNB2 (zeige CACNB2 Proteine) genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.

  5. Functional expression of CACNA2D1 is inhibited by prion protein (zeige PRNP Proteine) expression with competition at glycosylphosphatidylinositol.

  6. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1.

  7. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate (zeige GRIN1 Proteine) release, yet inhibits this release in wild-type mice.

  8. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS (zeige ANO6 Proteine).

  9. CACNA2D1 is a novel Brugada Syndrome susceptibility gene.

  10. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation

Rabbit Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartner

  1. data support a model in which small neutral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at the predicted membrane interface and further suggest that preventing GPI (zeige GPI Proteine) anchoring of CaValpha2delta1 averts its cell-surface expression

  2. these findings provide evidence for a new role of Homer1 (zeige HOMER1 Proteine) supporting the regulation of Cav1.2 (zeige CACNA1C Proteine) channels by STIM1 (zeige STIM1 Proteine).

Pig (Porcine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartner

Cow (Bovine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartner

  1. The objective of the present study was to identify polymorphisms of the CACNA2D1 gene, and to analyze associations between these polymorphisms and mastitis in several cattle breeds.

  2. CACNA2D1 gene is one of the potential candidate genes influencing carcass and meat quality traits.

Mouse (Murine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) Interaktionspartner

  1. Loss of the Ca(2 (zeige CA2 Proteine)+) channel alpha2delta-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner.

  2. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 may contribute to individual differences in von Frey filament response.

  3. a TSP4 (zeige THBS4 Proteine)/Cavalpha2delta1-dependent pathway activated by TSP4 (zeige THBS4 Proteine) or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis.

  4. CaV2.2 (zeige CACNA1B Proteine) and alpha2delta-1 are intimately associated at the plasma membrane

  5. These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2 (zeige CA2 Proteine)+) current regulating neurotransmitter release from photoreceptor terminals

  6. Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety.

  7. This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus

  8. association of calcium channel alpha2/delta subunit 1 and ATP5b (zeige ATP5B Proteine) occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients

  9. mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate (zeige GRIN1 Proteine) release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli.

CACNA2D1 Protein Überblick

Protein Überblick

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Genbezeichner und Symbole assoziert mit CACNA2D1

  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (CACNA2D1)
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (cacna2d1)
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (Cacna2d1)
  • calcium channel, voltage-dependent, alpha2/delta subunit 1 (Cacna2d1)
  • Ca(v)alpha2delta1 Protein
  • Cacna2 Protein
  • CACNA2D1 Protein
  • CACNL2A Protein
  • Cchl2a Protein
  • CCHLA2 Protein
  • DHSCCA Protein
  • DKFZp469K2211 Protein

Bezeichner auf Proteinebene für CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1 , voltage-dependent calcium channel subunit alpha-2/delta-1-like , calcium channel, L type, alpha 2 polypeptide , dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit , voltage-dependent calcium channel subunit alpha-2/delta-1 , voltage-gated calcium channel subunit alpha-2/delta-1 , dihydropryridine-sensitive calcium channel alpha-2 subunit , dihydropyridine-sensitive calcium channel alpha 2 , Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)

GENE ID SPEZIES
463504 Pan troglodytes
708215 Macaca mulatta
100012746 Monodelphis domestica
100036724 Xenopus (Silurana) tropicalis
100171724 Pongo abelii
100463812 Ailuropoda melanoleuca
100566428 Anolis carolinensis
100595072 Nomascus leucogenys
781 Homo sapiens
100009105 Oryctolagus cuniculus
100728887 Cavia porcellus
768444 Gallus gallus
610342 Canis lupus familiaris
397377 Sus scrofa
282608 Bos taurus
12293 Mus musculus
25399 Rattus norvegicus
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