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CDH20 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. Zusätzlich bieten wir Ihnen Cadherin 20 Proteine (8) und Cadherin 20 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CDH20 Primary Antibody für IF, IHC - ABIN1534289
Kools, Van Imschoot, van Roy: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. in Genomics 2000
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Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20.
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.
, F-cadherin short isoform
, cadherin 20
, fibroblast cadherin FIB2
, fibroblast cadherin-2
, protocadherin gamma-B4