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anti-Ca++-Dependent Secretion Activator 2 (CADPS2) Antikörper

CADPS2 encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Zusätzlich bieten wir Ihnen Ca++-Dependent Secretion Activator 2 Kits (3) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CADPS2 26989 Q62717
CADPS2 93664 Q86UW7
CADPS2 320405 Q8BYR5
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry of CAPS2 in human brain with CAPS2 antibody at 5 μg/ml. Western blot analysis of CAPS2 in human brain tissue lysate with CAPS2 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Anmelden zum Anzeigen 8 bis 10 Tage
357,50 €
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Human Kaninchen Unkonjugiert IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 15 Tage
412,82 €
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Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Alexa Fluor 647 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Biotin IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
366,11 €
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Human Kaninchen Cy3 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 17 Tage
388,17 €
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CADPS2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Rat (Rattus) , , , ,

Human , , , ,

Mouse (Murine) , , , ,

Am meisten referenzierte anti-Ca++-Dependent Secretion Activator 2 Antikörper

  1. Human Polyclonal CADPS2 Primary Antibody für EIA, IHC (p) - ABIN499527 : Sadakata, Washida, Furuichi: Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. in BMC neuroscience 2007 (PubMed)
    Zeige alle 3 Referenzen für ABIN499527

  2. Human Polyclonal CADPS2 Primary Antibody für IHC, ELISA - ABIN1001982 : Walent, Porter, Martin: A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. in Cell 1992 (PubMed)
    Zeige alle 3 Referenzen für ABIN1001982

Weitere Antikörper gegen Ca++-Dependent Secretion Activator 2 Interaktionspartner

Human Ca++-Dependent Secretion Activator 2 (CADPS2) Interaktionspartner

  1. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR (zeige DRD2 Antikörper) interaction.

  2. We speculate that haploinsufficiency of CADPS2 contributes to ASDs.

  3. identification, cloning, and comparative characterization of a second mammalian CAPS (zeige CAPS Antikörper) isoform, CAPS2 (zeige CAPS2 Antikörper); concluded that at the functional level, CAPS2 (zeige CAPS2 Antikörper) is largely redundant with CAPS1 (zeige CAPS Antikörper)

  4. Results from Cadps2-deficient mice and human data suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autistic-like cellular and behavioral phenotypes.

  5. CAPS (zeige CAPS Antikörper) proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 (zeige SLC18A1 Antikörper) and VMAT2 (zeige Slc18a2 Antikörper)

Mouse (Murine) Ca++-Dependent Secretion Activator 2 (CADPS2) Interaktionspartner

  1. CAPS2 plays an important role in subcellular locality (axonal vs. somato (zeige SSTR5 Antikörper)-dendritic) of enhanced BDNF (zeige BDNF Antikörper) and NT-3 (zeige NTF3 Antikörper) release, which is indispensable for proper development of postnatal cerebellum.

  2. Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.

  3. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF (zeige BDNF Antikörper) and causes autistic-like behavior in mice

  4. identification, cloning, and comparative characterization of a second mammalian CAPS (zeige CAPS Antikörper) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (zeige CAPS Antikörper)

  5. results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 (zeige NTF3 Antikörper) and BDNF (zeige BDNF Antikörper) from granule cells, leading to regulation in cell differentiation and survival during cerebellar development

  6. CADPS2-KO mice show autistic-like phenotypes. Moreover, the results show that some autistic patients have an aberrant splicing variant of CADPS2 mRNA, suggesting that a disturbance in CADPS2-mediated neurotrophin (zeige BDNF Antikörper) release contributes to autism.

  7. CADPS2/CAPS2-knockout mice exhibit pronounced impairments in cerebellar development and functions. These results are also suggestive of an involvement of the CADPS2/CAPS2 gene, which is located within the AUTS1, in the cerebellar deficits of autism.

  8. The results show the immunohistochemical localization of the CAPS (zeige CAPS Antikörper) family proteins in various mouse tissues.

  9. The two CAPS (zeige CAPS Antikörper) family proteins are complementarily distributed throughout the various brain regions of mice.

Ca++-Dependent Secretion Activator 2 (CADPS2) Antigen-Profil

Protein Überblick

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CADPS2

  • Ca++-dependent secretion activator 2 (CADPS2) Antikörper
  • Ca++-dependent secretion activator (Cadps) Antikörper
  • Ca++-dependent secretion activator 2 (Cadps2) Antikörper
  • Ca2+-dependent activator protein for secretion 2 (Cadps2) Antikörper
  • A230044C21Rik Antikörper
  • Caps Antikörper
  • Caps-2 Antikörper
  • Caps1 Antikörper
  • Caps2 Antikörper
  • Cpd2 Antikörper
  • RGD1559440 Antikörper

Bezeichner auf Proteinebene für CADPS2

Ca2+-dependent activator protein for secretion 2 , Ca++-dependent secretion activator 2 , CAPS-1 , Ca2+-dependent activator protein , Ca2+-dependent secretion activator , Ca<2+-dependent activator protein for secretion , calcium-dependent activator protein for secretion 1 , calcium-dependent secretion activator 1 , rCAPS , CAPS-2 , calcium-dependent activator protein for secretion 2 , calcium-dependent secretion activator 2 , cerebellum postnatal development associated protein 2

GENE ID SPEZIES
100056300 Equus caballus
472494 Pan troglodytes
26989 Rattus norvegicus
93664 Homo sapiens
312166 Rattus norvegicus
475304 Canis lupus familiaris
100525671 Sus scrofa
519444 Bos taurus
320405 Mus musculus
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