C-Type Lectin Domain Family 4, Member G Proteine (CLEC4G)

CLEC4G encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Zusätzlich bieten wir Ihnen CLEC4G Antikörper (26) und CLEC4G Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte CLEC4G CLEC4G 689004  
CLEC4G 339390 Q6UXB4
CLEC4G 75863 Q8BNX1
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Showing 4 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
HEK-293 Cells Human Fc Tag Human LSECtin, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%. 50 μg Anmelden zum Anzeigen 21 bis 31 Tage
$319.00
Details
HEK-293 Human Fc Tag   0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$584.38
Details

CLEC4G Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)
,

Weitere Proteine zu C-Type Lectin Domain Family 4, Member G (CLEC4G) Interaktionspartnern

Pig (Porcine) C-Type Lectin Domain Family 4, Member G (CLEC4G) Interaktionspartner

  1. In this study, there was experimentally identified the cDNA and the gene encoding porcine CLEC4G.

Human C-Type Lectin Domain Family 4, Member G (CLEC4G) Interaktionspartner

  1. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN (zeige CD209 Proteine), DC-SIGNR (zeige CLEC4M Proteine) and LSECtin.

  2. The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation.

  3. The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2 (zeige CA2 Proteine)+) and N-acetylglucosamine.

  4. Axl (zeige AXL Proteine),Tyro3 (zeige TYRO3 Proteine),DC-SIGN (zeige CD209 Proteine) and LSECtin are identified as new virus receptors for Lassa virus cell entry.

  5. The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction.

  6. The interaction between CD44 (zeige CD44 Proteine) & LSECtin is dependent on protein-glycan recognition. CD44 (zeige CD44 Proteine) is the 1st identified endogenous ligand of LSECtin, & similarly, LSECtin is a novel ligand of CD44 (zeige CD44 Proteine).

  7. results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor

  8. LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization

  9. Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN (zeige CD209 Proteine)/R and LSECtin and hint towards different biological functions of these lectins.

  10. LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor.

Mouse (Murine) C-Type Lectin Domain Family 4, Member G (CLEC4G) Interaktionspartner

  1. This study shows that C-type lectin LSECtin, a member of the DC-SIGN (zeige CD209 Proteine) family, is a novel liver regulator for natural killer cells (NK cells). LSECtin could bind to NK cells in a carbohydrate-dependent manner and could regulate the number of hepatic NK cells.

  2. Data show that C-type lectin-like domain family 4, member g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving enzyme-1 (BACE1 (zeige BACE Proteine))-mediated amyloid-beta (Abeta (zeige APP Proteine)) peptides generation.

  3. When expressed in B16 melanoma cells, LSECtin promoted tumor growth, whereas its blockade slowed tumor growth in either wild-type or LSECtin-deficient mice.

  4. LSECtin-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of Cbl-b.

  5. LSECtin may facilitate the reduction of liver inflammation at the cost of delaying virus clearance, an effect that might be hijacked by the virus as an escape mechanism.

  6. The studies provide a basis for using mouse LSECtin, and knockout mice lacking this receptor, to model the biological properties of the human receptor.

  7. Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.

CLEC4G Protein Überblick

Protein Überblick

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CLEC4G

  • C-type lectin domain family 4 member G (CLEC4G)
  • C-type lectin domain family 4, member G (Clec4g)
  • C-type lectin domain family 4, member g (Clec4g)
  • 4930572L20Rik Protein
  • DTTR431 Protein
  • LP2698 Protein
  • LSECtin Protein
  • RGD1562320 Protein
  • UNQ431 Protein

Bezeichner auf Proteinebene für CLEC4G

C-type lectin domain family 4, member G , C-type lectin superfamily 4, member G , C-type lectin domain family 4 member G , DC-SIGN related C-type lectin , LSECtin , liver and lymph node sinusoidal endothelial cell C-type lectin

GENE ID SPEZIES
484999 Canis lupus familiaris
507332 Bos taurus
689004 Rattus norvegicus
742238 Pan troglodytes
100240718 Sus scrofa
339390 Homo sapiens
75863 Mus musculus
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