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The protein encoded by CDC14A is a member of the dual specificity protein tyrosine phosphatase family. Zusätzlich bieten wir Ihnen CDC14A Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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We demonstrate that XCdc14A upregulation prevents targeting of exocyst and SNARE (zeige NAPA Antikörper) complexes to the midbody, both essential for abscission to occur.
Cdc14B (zeige CDC14B Antikörper) knockout (Cdc14B (zeige CDC14B Antikörper)(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness.
Overexpressed miR (zeige MLXIP Antikörper)-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR (zeige MLXIP Antikörper)- 301a may be useful for osteosarcoma diagnosis and therapy.
These findings indicated that ZIPK (zeige DAPK3 Antikörper) may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A.
These data support the hypothesis that Cdc14A counteracts Cdk1 (zeige CDK1 Antikörper)-cyclin B1 (zeige CCNB1 Antikörper) activity through Wee1 (zeige WEE1 Antikörper) dephosphorylation.
CDC (zeige CDK1 Antikörper) (cell division cycle) 14A/B phosphatases associate with KIBRA (zeige WWC1 Antikörper), and CDK1 (zeige CDK1 Antikörper)-non-phosphorylatable KIBRA (zeige WWC1 Antikörper) has greatly reduced interaction with CDC14B (zeige CDC14B Antikörper).
Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.
Cdc14A phosphatase prevents premature activation of Cdk1 (zeige CDK1 Antikörper) regulating Cdc25A (zeige CDC25A Antikörper) and Cdc25B (zeige CDC25B Antikörper) at the entry into mitosis.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
human Cdc14A phosphatase disrupts centrosome separation
hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14A
, dual specificity protein phosphatase CDC14A
, CDC14 cell division cycle 14 homolog A
, cell division cycle 14 homolog A
, CDC14 homolog A
, CDC14 cell division cycle 14 homolog A (S. cerevisiae)
, dual specificity protein phosphatase CDC14A-like
, CDC10 (cell division cycle 10, S. cerevisiae, homolog)