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The protein encoded by CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Zusätzlich bieten wir Ihnen CD63 Antikörper (568) und CD63 Kits (33) und viele weitere Produktgruppen zu diesem Protein an.
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In renal proximal tubules, CD63 determines the insertion of OCT2 (zeige SLC22A2 Proteine) into the proper membrane domain and mediates transporter regulation by trafficking processes.
TIMP1 (zeige TIMP1 Proteine) signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.
The Muted protein (zeige MUTED Proteine) is important for the steady-state level of CD63.
Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity.
These findings identify CD63 as an important component of allergic inflammation.
CD63 serves to bridge between beta1 integrin and VEGFR2 (zeige KDR Proteine) because CD63 silencing disrupted VEGFR2 (zeige KDR Proteine)-beta1 integrin complex formation identified using proximity ligation assay
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
Loss of CD63 has a similar phenotype to loss of P-selectin (zeige SELP Proteine) itself, thus CD63 is an essential cofactor to P-selectin (zeige SELP Proteine).
CXCR4 (zeige CXCR4 Proteine) can be downregulated on activated B cells by IL-21 (zeige IL21 Proteine)-induced endocytosis and CD63-mediated endosomal recruitment.
The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII (zeige SYT7 Proteine) is targeted to lysosomes.
CD63 and exosome expression is altered in scleroderma dermal fibroblasts
CD63 is a critical player in LMP1 (zeige PDLIM7 Proteine) exosomal trafficking and LMP1 (zeige PDLIM7 Proteine)-mediated enhancement of exosome production and may play further roles in limiting downstream LMP1 (zeige PDLIM7 Proteine) signaling.
Concentrations of Cd63 were elevated in gingival crevicular fluid of patients with pre-eclampsia.
CD163 (zeige CD163 Proteine)(+) TAMs in oral premalignant lesions coexpress CD163 (zeige CD163 Proteine) and STAT1 (zeige STAT1 Proteine), suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1 (zeige TH1L Proteine)-dominated micromilieu.
Our findings reveal that elevated levels of TIMP-1 (zeige TIMP1 Proteine) impact on neutrophil homeostasis via signaling through CD63.
These findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K (zeige PIK3CA Proteine)/pAkt (zeige AKT1 Proteine) signaling pathway
It was shown that treatment of macrophages with anti-CD63 inhibits CCR5-mediated virus infection in a cell type-specific manner, but that no inhibition of CXCR4 (zeige CXCR4 Proteine)-tropic viruses occurs.
TM4SF5 interacted with CD151 (zeige CD151 Proteine), and caused the internalization of CD63 from the cell surface.
Diesel exhaust exposure during exercise induces platelet activation as illustrated by a dose-response increase in the release of CD62P (zeige SELP Proteine) and CD63.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
melanoma 1 antigen
, CD63 antigen
, CD63 antigen (melanoma 1 antigen)
, lysosomal-associated membrane protein 3
, lysosome-associated membrane glycoprotein 3
, melanoma-associated antigen ME491
, melanoma-associated antigen MLA1
, ocular melanoma-associated antigen
, ME491/CD63 antigen
, mast cell antigen AD1