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The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. Zusätzlich bieten wir Ihnen CEBPA Antikörper (151) und CEBPA Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human CEBPA ELISA Kit für Sandwich ELISA - ABIN414603
Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
results demonstrate that the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the C/EBP transcription factors in monocytic cells, and imply that the lowly expressed ACAT2 catalyzes the synthesis of certain CE/SE that are assembled into lipoproteins for the secretion
Our study highlighted two novel promoter KLF1 and 3'-region C/EBPalpha motifs in the phenylalanine hydroxylase (PAH) gene which decrease transcription in vitro and, thus, could be considered as PAH expression modifiers.
The QA repeat domain of TCERG1 (zeige TCERG1 ELISA Kits) is required for relocalization of CEBPalpha.
In the CCAAT/enhancer binding protein alpha gene, no mutations were detected but a known polymorphism (c.584_589dup ACCCGC) was observed in 26 (28.3%) patients.
The p53 (zeige TP53 ELISA Kits)-KLF4 (zeige KLF4 ELISA Kits)-CEBPA axis is deregulated in AML (zeige RUNX1 ELISA Kits) but can be functionally restored by conventional chemotherapy and novel p53 (zeige TP53 ELISA Kits) activating treatments.
C/EBPalpha inhibited breast cancer cell growth via a novel miR (zeige MLXIP ELISA Kits)-134/CREB (zeige CREB1 ELISA Kits) signaling pathway.
C/EBP-alpha was primarily expressed in hepatocytes in normal liver, but its expression decreased significantly in liver fibrosis
The efficient repression of E2F (zeige E2F1 ELISA Kits) dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBP alpha.
we are the first to identify that miR (zeige MLXIP ELISA Kits)-381 suppresses C/EBPalpha-dependent Cx43 (zeige GJA1 ELISA Kits) expression in breast cancer cells. The miR (zeige MLXIP ELISA Kits)-381-C/EBPalpha-Cx43 (zeige GJA1 ELISA Kits) axis might be a useful diagnostic and therapeutic target of metastatic breast cancer
results suggested that C/EBPalpha-saRNA successfully inhibited HCC (zeige FAM126A ELISA Kits) metastasis by inhibiting EGFR (zeige EGFR ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway mediated EMT (zeige ITK ELISA Kits) in vitro and in vivo
the DNA sequences to which EVI1 (zeige MECOM ELISA Kits) binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1 (zeige MECOM ELISA Kits)-induced suppression.
Cebpa enhancers and silencers in a transcriptional model have roles in hematopoietic lineage specification
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha) directly regulates Kruppel-like factor 4 (Klf4 (zeige KLF4 ELISA Kits)) expression and increasing the levels of histone demethylase (zeige MBD2 ELISA Kits) Lsd1 (zeige KDM1A ELISA Kits) and transcription factor Brd4 (zeige BRD4 ELISA Kits) in B cell.
The findings demonstrate a critical role for the +37 kb Cebpa enhancer for hematopoietic-specific Cebpa expression, with enhancer deletion leading to impaired myelopoiesis and potentially preleukemic progenitor expansion.
Data indicate that miR (zeige MLXIP ELISA Kits)-25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3-L1 adipogenesis by targeting KLF4 (zeige KLF4 ELISA Kits) and C/EBPalpha, which provides novel insights into the molecular mechanism of miRNA-mediated cellular differentiation.
MYB (zeige MYB ELISA Kits) and C/EBPalpha activities are inter-dependent in controlling Flt3 (zeige FLT3 ELISA Kits) expression to influence lineage commitment of multipotential progenitors.
Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a (zeige FCER1A ELISA Kits)(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG ELISA Kits)).
miR (zeige MLXIP ELISA Kits)-223 regulates adipocyte and osteoblast differentiation through a novel C/EBPs/miR (zeige MLXIP ELISA Kits)-223/FGFR2 (zeige FGFR2 ELISA Kits) regulatory feedback loop.
Data (including data from studies in transgenic/mutant mice) suggest Cebpa (CCAAT-enhancer binding protein alpha) in myeloid cells is down-regulated in type 2 diabetes resulting in poor maturation of Gr-1 (zeige GSR ELISA Kits)+ (chemokine receptor (zeige CCR1 ELISA Kits)) myeloid cells.
C/ebpalpha plays a role in liver growth regulation via the p53 (zeige TP53 ELISA Kits) pathway.
Dnmt1 (zeige DNMT1 ELISA Kits) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (zeige ALDH1L1 ELISA Kits)) involving CEBPalpha helps relieve embryonic oxidative stress induced (zeige SQSTM1 ELISA Kits) by ethanol exposure.
Bmi1 (zeige BMI1 ELISA Kits) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (zeige SUMO1 ELISA Kits), SUMO2 (zeige SUMO2 ELISA Kits), and SUMO3 (zeige SUMO3 ELISA Kits)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (zeige CTNNA1 ELISA Kits) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (zeige IL6 ELISA Kits)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (zeige MSTN ELISA Kits) in muscles were higher in the concentrate-fed group than in the grass hay (zeige GTF2H5 ELISA Kits)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha