Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) ELISA Kits

BUB1B encodes a kinase involved in spindle checkpoint function. Zusätzlich bieten wir Ihnen BUB1B Antikörper (180) und BUB1B Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human BUB1B BUB1B 701 O60566
Anti-Ratte BUB1B BUB1B 171576  
BUB1B 12236 Q9Z1S0
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 9.38 pg/mL 37.5-2400 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
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Weitere ELISA Kits für BUB1B Interaktionspartner

Xenopus laevis Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaktionspartner

  1. Together, our findings demonstrate that Bub1 (zeige BUB1 ELISA Kits) acts at multiple points to assure the correct kinetochore formation.

Fruit Fly (Drosophila melanogaster) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaktionspartner

  1. The Bub3 (zeige BUB3 ELISA Kits)-BubR1 complex on broken DNA inhibits the APC (zeige APC ELISA Kits)/C locally via the sequestration of Cdc20 (zeige CDC20 ELISA Kits).

  2. a model in which Polo (zeige PLK1 ELISA Kits) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (zeige CDC20 ELISA Kits) kinetochore recruitment and sustained SAC (zeige ADCY10 ELISA Kits) function.

  3. Data show that the Mad2 (zeige MAD2L1 ELISA Kits) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (zeige CDC20 ELISA Kits) to kinetochores in Drosophila requires BubR1 but not Mad2 (zeige MAD2L1 ELISA Kits).

  4. Reduced BubR1 or Polo (zeige PLK1 ELISA Kits) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.

  5. BubR1's role in mitosis is discussed.

  6. BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis

  7. BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (zeige CENPE ELISA Kits).

  8. Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (zeige CDC20 ELISA Kits)-APC (zeige APC ELISA Kits) function, preventing the metaphase-to-anaphase transition.

Human Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaktionspartner

  1. Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

  2. BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (zeige CDC20 ELISA Kits)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.

  3. Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.

  4. Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (zeige MYO5A ELISA Kits) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors

  5. structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets.

  6. Overexpression of BUB1B is associated with Invasive Breast Cancer.

  7. we showed that BubR1 and Mad2 (zeige MAD2L1 ELISA Kits) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.

  8. The integrity of the mitotic checkpoint (zeige BUB3 ELISA Kits) complex depends on the specific recognition between BubR1 and Bub3 (zeige BUB3 ELISA Kits), for which the BubR1 Gle2 (zeige RAE1 ELISA Kits) binding sequence motif is essential.

  9. We show that kinetochore recruitment of BUBR1 and BUB3 (zeige BUB3 ELISA Kits) by BUB1 (zeige BUB1 ELISA Kits) is dispensable for SAC (zeige ADCY10 ELISA Kits) activation

  10. Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) Interaktionspartner

  1. Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

  2. Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.

  3. EZH2 (zeige EZH2 ELISA Kits) directly interacted with and stabilized BubR1, an effect driving EZH2 (zeige EZH2 ELISA Kits) into the concert of meiosis regulation.

  4. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (zeige BUB3 ELISA Kits), and Ercc1 (zeige ERCC1 ELISA Kits)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (zeige ERCC1 ELISA Kits)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  5. Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (zeige SGOL1 ELISA Kits) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  6. These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.

  7. BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.

  8. Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.

  9. the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (zeige SIRT2 ELISA Kits) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (zeige CREBBP ELISA Kits).

  10. BubR1 insufficiency elicits an aging response that is counteracted by p53 (zeige TP53 ELISA Kits) and involves single or multiple p53 (zeige TP53 ELISA Kits) targets, depending on the tissue type.

BUB1B Antigen-Profil

Beschreibung des Gens

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Genbezeichner und Symbole assoziert mit BUB1B

  • BUB1B, mitotic checkpoint serine/threonine kinase L homeolog (bub1b.L) Antikörper
  • BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) Antikörper
  • BUB1B, mitotic checkpoint serine/threonine kinase (bub1b) Antikörper
  • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (bub1b) Antikörper
  • Bub1 kinase (Bub1) Antikörper
  • Bub1-related kinase (BubR1) Antikörper
  • BUB1 mitotic checkpoint serine/threonine kinase B (Bub1b) Antikörper
  • BUB1B, mitotic checkpoint serine/threonine kinase (Bub1b) Antikörper
  • 31/13 Antikörper
  • AU045529 Antikörper
  • BcDNA:LD23835 Antikörper
  • Bub1 Antikörper
  • BUB1-like Antikörper
  • Bub1A Antikörper
  • bub1b Antikörper
  • BUB1beta Antikörper
  • bubr1 Antikörper
  • BubRI Antikörper
  • CG7838 Antikörper
  • CG 7838 Antikörper
  • CG14030 Antikörper
  • CG14030/Bub1 Antikörper
  • dBUB1 Antikörper
  • Dmbub1 Antikörper
  • Dmel\\CG7838 Antikörper
  • Dmel\\CG14030 Antikörper
  • hBUBR1 Antikörper
  • l(2)k03113 Antikörper
  • l(2)k06109 Antikörper
  • MAD3L Antikörper
  • mcl(2)Z1525 Antikörper
  • MVA1 Antikörper
  • SSK1 Antikörper

Bezeichner auf Proteinebene für BUB1B

BUB1 budding uninhibited by benzimidazoles 1 homolog beta , budding uninhibited by benzimidazoles 1 beta , budding uninhibited by benzimidazoles 1 homolog beta , mitotic checkpoint serine/threonine-protein kinase BUB1 beta , budding uninhibited by benzimidazoles 1 homolog beta (yeast) , mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like , Bub1-PA , CG14030-PA , Bub1 , BubR1-PA , CG7838-PA , bub related one , mcl(2)Z1525 , MAD3/BUB1-related protein kinase , mitotic checkpoint kinase MAD3L , budding uninhibited by benzimidazoles 1 homolog, beta

GENE ID SPEZIES
378923 Xenopus laevis
453324 Pan troglodytes
537027 Bos taurus
100125106 Xenopus (Silurana) tropicalis
100196482 Salmo salar
100413586 Callithrix jacchus
100423079 Macaca mulatta
100455824 Pongo abelii
100464546 Ailuropoda melanoleuca
100607252 Nomascus leucogenys
100629735 Equus caballus
33758 Drosophila melanogaster
35522 Drosophila melanogaster
378922 Gallus gallus
701 Homo sapiens
171576 Rattus norvegicus
608350 Canis lupus familiaris
12236 Mus musculus
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