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BUB1B encodes a kinase involved in spindle checkpoint function. Zusätzlich bieten wir Ihnen BUB1B Proteine (8) und BUB1B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 180 products:
Human Monoclonal BUB1B Primary Antibody für CyTOF, FACS - ABIN151818
Chan, Jablonski, Sudakin, Hittle, Yen: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. in The Journal of cell biology 1999
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Human Polyclonal BUB1B Primary Antibody für IP, WB - ABIN152011
Tang, Erikson, Liu: Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Monoclonal BUB1B Primary Antibody für IHC (p), PLA - ABIN560109
Chambers: The molecular basis of pluripotency in mouse embryonic stem cells. in Cloning and stem cells 2005
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Human Polyclonal BUB1B Primary Antibody für WB - ABIN2801914
Donadelli, Benatti, Remuzzi, Morigi, Gullans, Benigni, Remuzzi, Noris: Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress. in Biochemical and biophysical research communications 1998
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Human Monoclonal BUB1B Primary Antibody für IF, WB - ABIN968854
Mizunuma, Hirata, Miyahara, Tsuchiya, Miyakawa: Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. in Nature 1998
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Human Monoclonal BUB1B Primary Antibody für IF, WB - ABIN968853
Wu, Lan, Li, Wu, Weinstein, Sakamoto, Dai: p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. in Oncogene 2000
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Human Polyclonal BUB1B Primary Antibody für ICC, IF - ABIN251710
On, Chen, Ma, Chow, Poon: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. in Molecular cancer therapeutics 2011
Human Polyclonal BUB1B Primary Antibody für IF (p), IHC (p) - ABIN713831
Qu, Zou, Zhang, Sheng, Wang, Wang, Wang, Ji: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. in Molecular medicine reports 2016
Human Monoclonal BUB1B Primary Antibody für ICC, IF - ABIN2668286
Liu, Rattner, Jablonski, Yen: Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. in The Journal of cell biology 2006
Together, our findings demonstrate that Bub1 (zeige BUB1 Antikörper) acts at multiple points to assure the correct kinetochore formation.
The Bub3 (zeige BUB3 Antikörper)-BubR1 complex on broken DNA inhibits the APC (zeige APC Antikörper)/C locally via the sequestration of Cdc20 (zeige CDC20 Antikörper).
a model in which Polo (zeige PLK1 Antikörper) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (zeige CDC20 Antikörper) kinetochore recruitment and sustained SAC (zeige ADCY10 Antikörper) function.
Data show that the Mad2 (zeige MAD2L1 Antikörper) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (zeige CDC20 Antikörper) to kinetochores in Drosophila requires BubR1 but not Mad2 (zeige MAD2L1 Antikörper).
Reduced BubR1 or Polo (zeige PLK1 Antikörper) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
BubR1's role in mitosis is discussed.
BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis
BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (zeige CENPE Antikörper).
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (zeige CDC20 Antikörper)-APC (zeige APC Antikörper) function, preventing the metaphase-to-anaphase transition.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (zeige CDC20 Antikörper)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (zeige MYO5A Antikörper) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (zeige PPP2R4 Antikörper) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (zeige PPP2R4 Antikörper) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (zeige MAD2L1 Antikörper) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (zeige BUB3 Antikörper) complex depends on the specific recognition between BubR1 and Bub3 (zeige BUB3 Antikörper), for which the BubR1 Gle2 (zeige RAE1 Antikörper) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (zeige BUB3 Antikörper) by BUB1 (zeige BUB1 Antikörper) is dispensable for SAC (zeige ADCY10 Antikörper) activation
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (zeige EZH2 Antikörper) directly interacted with and stabilized BubR1, an effect driving EZH2 (zeige EZH2 Antikörper) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (zeige BUB3 Antikörper), and Ercc1 (zeige ERCC1 Antikörper)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (zeige ERCC1 Antikörper)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (zeige SGOL1 Antikörper) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (zeige SIRT2 Antikörper) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (zeige CREBBP Antikörper).
BubR1 insufficiency elicits an aging response that is counteracted by p53 (zeige TP53 Antikörper) and involves single or multiple p53 (zeige TP53 Antikörper) targets, depending on the tissue type.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like
, bub related one
, MAD3/BUB1-related protein kinase
, mitotic checkpoint kinase MAD3L
, budding uninhibited by benzimidazoles 1 homolog, beta