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BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. Zusätzlich bieten wir Ihnen BLOC1S1 Antikörper (18) und BLOC1S1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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The mitochondrial acetylation status controlled by Sirt3 (zeige SIRT3 ELISA Kits) and its proposed opponent GCN5L1 is an important regulator of the metabolic adaptation of mitochondrial translation.
Using cancer cell lines, the study shows that BLOC1S1 mRNA is specifically cleaved by IRE1 (zeige ERN1 ELISA Kits) at guanine 444, but only under conditions of IRE1 (zeige ERN1 ELISA Kits) hyperactivation.
The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton.
BLOS1 interacts with KXD1.
GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria.
Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility.
Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis.
Experimental investigation of five specific genes, AP3B1 (zeige AP3B1 ELISA Kits), ATP6AP1 (zeige ATP6AP1 ELISA Kits), BLOC1S1, LAMP2 (zeige LAMP2 ELISA Kits), and RAB11A (zeige RAB11A ELISA Kits), has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.
Biogenesis of Lysosome-related Organelles co (zeige SNAPIN ELISA Kits)mplex-1 (BLOC-1) subunit 1 (BLOS1).
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
TDH, responsible for mitochondrial production of acetyl-CoA (zeige LPCAT1 ELISA Kits) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15 (zeige FBXO15 ELISA Kits), an F-box protein (zeige FBXO30 ELISA Kits) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
BLOS1 interacts with sorting nexin 2 (zeige SNX2 ELISA Kits) and the ESCRT-I (zeige VPS28 ELISA Kits) component TSG101 (zeige TSG101 ELISA Kits) to mediate the sorting of EGFR (zeige EGFR ELISA Kits) into endosomal compartments
Here we show that genetic deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB), which acts as a master regulator of autophagy.
Mutations in the human genes encoding Snapin (zeige SNAPIN ELISA Kits) and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models
Defects in all the 5 known components of BLOC-1 (zeige PLDN ELISA Kits), including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 (zeige PLDN ELISA Kits) plays a key role in organelle biogenesis.
These results indicate that the BLOC-1 (zeige PLDN ELISA Kits) and AP-3 (zeige AP3B1 ELISA Kits) protein complexes affect the targeting of SNARE (zeige VTI1B ELISA Kits) and non-SNARE (zeige VTI1B ELISA Kits) AP-3 (zeige AP3B1 ELISA Kits) cargoes and suggest a function of the BLOC-1 (zeige PLDN ELISA Kits) complex in membrane protein sorting.
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004
BLOC subunit 1
, BLOC-1 subunit 1
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1
, GCN5 general control of amino-acid synthesis 5-like 1
, GCN5-like protein 1
, MTA1-interacting coactivator
, biogenesis of lysosome-related organelles complex 1 subunit 1
, biogenesis of lysosome-related organelles complex-1, subunit 1
, GCN5 general control of amino acid synthesis-like 1
, general control of amino acid synthesis, yeast homolog-like 1
, general control of amino acid synthesis-like 1