BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) ELISA Kits

BRF1 encodes one of the three subunits of the RNA polymerase III transcription factor complex. Zusätzlich bieten wir Ihnen BRF1 Antikörper (71) und BRF1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus BRF1 BRF1 72308  
Anti-Human BRF1 BRF1 2972 Q92994
Anti-Ratte BRF1 BRF1 299347  
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Weitere ELISA Kits für BRF1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) Interaktionspartner

  1. Results indicate that a portion of Brf1 is sandwiched between Bdp1 and TBP (zeige TBP ELISA Kits) upstream of the U6 TATA box. Furthermore, Bdp1 traverses the DNA under the N-terminal stirrup of TBP (zeige TBP ELISA Kits) to interact with the DNA (and very likely Brf1) downstream of the TATA sequence.

  2. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription

Mouse (Murine) BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) Interaktionspartner

  1. Brf1 (zfp36l1 (zeige ZFP36L1 ELISA Kits)), an AU-rich element mRNA-binding protein from the Zfp36 (zeige ZFP36 ELISA Kits) protein family, operates downstream of FGF/Erk MAP kinase (zeige MAPK1 ELISA Kits) signaling to regulate pluripotency and cell fate decision making in mouse embryonic stem cells.

  2. Alcohol induces RNA polymerase III-dependent transcription through c-Jun (zeige JUN ELISA Kits) by co-regulating TATA-binding protein (TBP (zeige TBP ELISA Kits)) and Brf1 (zeige ZFP36L1 ELISA Kits) expression.

  3. Phosphorylation at serine-92 and serine-203 is involved in BRF1 (zeige ZFP36L1 ELISA Kits) protein stability; high BRF1 (zeige ZFP36L1 ELISA Kits) protein levels are required to reinstate decay upon dissipation of the stabilizing signal.

Human BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) Interaktionspartner

  1. Site-directed mutagenesis combined with kinase assays and specific phosphosite immunodetection identified Ser (zeige SIGLEC1 ELISA Kits)-54 (S54) and Ser (zeige SIGLEC1 ELISA Kits)-334 (S334) as PKA target amino acids in vitro and in vivo. Phosphomimetic mutation of the C-terminal S334 markedly increased TIS11b (zeige ZFP36L1 ELISA Kits) half-life and, unexpectedly, enhanced TIS11b (zeige ZFP36L1 ELISA Kits) activity on mRNA decay.

  2. Mutations in BRF1 (zeige ZFP36L1 ELISA Kits) cause severe short stature, remarkably delayed bone age, dysmorphic features, cerebellar hypoplasia and cognitive dysfunction inherited in an autosomal recessive pattern.

  3. Brf1 (zeige ZFP36L1 ELISA Kits) expression is increased in human HCC (zeige FAM126A ELISA Kits) cases, which is correlated with shorter survival times.

  4. BRF1 mutations that reduce protein activity cause neurodevelopmental anomalies, suggesting that BRF1-mediated Pol III transcription is required for normal cerebellar and cognitive development.

  5. hnRNP F (zeige HNRNPF ELISA Kits) is a co-factor in a subset of tristetraprolin (zeige ZFP36 ELISA Kits)/BRF1 (zeige ZFP36L1 ELISA Kits)/BRF2 (zeige ZFP36L2 ELISA Kits)-mediated mRNA decay.

  6. these observations are in favor of a cell- and context-dependent regulation of Tis11b (zeige ZFP36L1 ELISA Kits) by hypoxia, which then contributes to modulation of angiogenesis.

  7. Alcohol induces RNA polymerase III-dependent transcription through c-Jun (zeige JUN ELISA Kits) by co-regulating TATA-binding protein (TBP (zeige TBP ELISA Kits)) and Brf1 (zeige ZFP36L1 ELISA Kits) expression.

  8. results identify a human Pol III isoform and isoform-specific functions in the regulation of cell growth and transformation

  9. CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells.

  10. BRF1 (zeige ZFP36L1 ELISA Kits) accelerated mRNA decay and antagonized the stabilizing effect of PI3-kinase (zeige PIK3CA ELISA Kits), while mutation of the zinc fingers abolished both function and ARE-binding activity. This approach identifies BRF1 (zeige ZFP36L1 ELISA Kits) as an essential regulator of ARE-dependent mRNA decay.

BRF1 Antigen-Profil

Beschreibung des Gens

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified.

Genbezeichner und Symbole assoziert mit BRF1

  • CG31256 gene product from transcript CG31256-RA (Brf) Antikörper
  • zgc:73380 (zgc:73380) Antikörper
  • general transcription factor IIB (GTF2B) Antikörper
  • transcription factor iib (PFE0415w) Antikörper
  • transcription factor IIB (Tb09.160.4220) Antikörper
  • transcription factor IIb (PVX_097980) Antikörper
  • transcription factor IIB (CpipJ_CPIJ011738) Antikörper
  • transcription factor IIB (CpipJ_CPIJ014799) Antikörper
  • transcription factor IIB (CpipJ_CPIJ018710) Antikörper
  • Transcription factor iib (PKH_102450) Antikörper
  • transcription initiation factor IIB (gtf2b) Antikörper
  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (BRF1) Antikörper
  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (Brf1) Antikörper
  • BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit (BRF1) Antikörper
  • BRF1, RNA polymerase III transcription initiation factor 90 subunit (Brf1) Antikörper
  • 2510002F24Rik Antikörper
  • brf Antikörper
  • BRF-1 Antikörper
  • BRF1 Antikörper
  • CG4155 Antikörper
  • CG5419 Antikörper
  • CG31256 Antikörper
  • DDBDRAFT_0189159 Antikörper
  • DDBDRAFT_0216283 Antikörper
  • DDB_0189159 Antikörper
  • DDB_0216283 Antikörper
  • Dmel\\CG31256 Antikörper
  • GTF2B Antikörper
  • GTF3B Antikörper
  • hBRF Antikörper
  • mTFIIIB90 Antikörper
  • TAF3B2 Antikörper
  • TAF3C Antikörper
  • TAFIII90 Antikörper
  • TF3B90 Antikörper
  • TFIIIB Antikörper
  • TFIIIB90 Antikörper
  • ZFP36L1 Antikörper

Bezeichner auf Proteinebene für BRF1

Brf-PA , Brf-PB , CG31256-PA , CG31256-PB , RNA Pol III transcription factor , UPF0468 protein C16orf80 homolog , transcription initiation factor IIB , general transcription factor IIB , transcription factor iib , transcription factor IIB , transcription factor IIb , Transcription factor iib , general transcription factor TFIIB , BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) , transcription initiation factor IIIB , zinc finger protein 36, C3H type-like 1 , B-related factor 1 , BRF-1 , hTFIIIB90 , transcription factor IIIB 90 kDa subunit , B - related factor 1 , BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB , TATA box binding protein (TBP)-associated factor 3C , TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2 , TBP - associated factor, RNA polymerase III, 90kD , general transcription factor IIIB, 90kD subunit

GENE ID SPEZIES
42087 Drosophila melanogaster
393784 Danio rerio
694770 Macaca mulatta
743356 Pan troglodytes
812860 Plasmodium falciparum 3D7
3660552 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5472512 Plasmodium vivax Sal-1
6044607 Culex quinquefasciatus
6048330 Culex quinquefasciatus
6052828 Culex quinquefasciatus
7321100 Plasmodium knowlesi strain H
8627902 Dictyostelium discoideum AX4
100173138 Pongo abelii
423503 Gallus gallus
453212 Pan troglodytes
490883 Canis lupus familiaris
72308 Mus musculus
2972 Homo sapiens
299347 Rattus norvegicus
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