anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) Antikörper

BCCIP product was isolated on the basis of its interaction with BRCA2 and p21 proteins. Zusätzlich bieten wir Ihnen BCCIP Proteine (9) und BCCIP Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BCCIP 56647 Q9P287
BCCIP 66165 Q9CWI3
BCCIP 361666  
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Top anti-BCCIP Antikörper auf antikoerper-online.de

Showing 10 out of 47 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert IF, WB Western blot analysis of TOK-1 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the Mouse Anti-TOK-1 antibody. Immunofluorescence staining of HeLa cells. 50 μg Anmelden zum Anzeigen 2 bis 4 Tage
209,60 €
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using BCCIP antibody. Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: BCCIP Antibody [NBP1-31319] - Sample (30 ug of whole cell lysate) A: A431 B: Hela 10% SDS PAGE; antibody diluted at 1:1000. Immunocytochemistry/Immunofluorescence: BCCIP Antibody [NBP1-31319] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IP, IHC, WB 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), IP, IHC Immunohistochemistry: BCCIP Antibody [NBP1-22994] - FPE section of human colon carcinoma. Antibody used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Maus Unkonjugiert DB 50 μg Anmelden zum Anzeigen 10 bis 13 Tage
281,63 €
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Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy7 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy5.5 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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BCCIP Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-BCCIP Antikörper

  1. Human Monoclonal BCCIP Primary Antibody für IF, WB - ABIN968821 : Liu, Yuan, Huan, Shen: Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. in Oncogene 2001 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen BCCIP Interaktionspartner

Human BRCA2 and CDKN1A Interacting Protein (BCCIP) Interaktionspartner

  1. this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression.

  2. Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells.

  3. we demonstrate that BCCIPbeta induces a conformational change within the RAD51 (zeige RAD51 Antikörper) filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 (zeige RAD51 Antikörper) accessory factor in HR.

  4. the existence of both INO80 (zeige INO80 Antikörper) and YY1 (zeige YY1 Antikörper) is required for recruiting the INO80 (zeige INO80 Antikörper)/YY1 (zeige YY1 Antikörper) complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80 (zeige INO80 Antikörper)/YY1 (zeige YY1 Antikörper) complex.

  5. The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 (zeige EIF6 Antikörper) and RPL23 (zeige RPL17 Antikörper)/UL14 and stabilizes the latter.

  6. Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population.

  7. In BRCA2 (zeige BRCA2 Antikörper), two novel frame shift mutations were identified as 5073-5074delCT and 6866delC.

  8. BRCA2 (zeige BRCA2 Antikörper) germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 (zeige BRCA2 Antikörper) mutations, since survival is higher among breast cancer patients carrying a BRCA2 (zeige BRCA2 Antikörper) mutation compared to sporadic breast cancers.

  9. Unique de novo mutation of BRCA2 (zeige BRCA2 Antikörper) has been identified in a woman with early onset breast cancer.

  10. Overexpression of BCCIP beta delays the G1 to S progression and results in an elevated p21 (zeige CDKN1A Antikörper) expression

Mouse (Murine) BRCA2 and CDKN1A Interacting Protein (BCCIP) Interaktionspartner

  1. BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression.

  2. BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors.

  3. these data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress

BCCIP Antigen-Profil

Protein Überblick

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BCCIP

  • BRCA2 and CDKN1A interacting protein (BCCIP) Antikörper
  • BRCA2 and CDKN1A interacting protein (bccip) Antikörper
  • BRCA2 and CDKN1A interacting protein (Bccip) Antikörper
  • 1110013J05Rik Antikörper
  • BCCIP Antikörper
  • DKFZp459K2416 Antikörper
  • MGC82792 Antikörper
  • MGC89311 Antikörper
  • mp:zf637-1-000774 Antikörper
  • TOK-1 Antikörper
  • TOK1 Antikörper
  • zgc:110272 Antikörper

Bezeichner auf Proteinebene für BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1

GENE ID SPEZIES
426225 Gallus gallus
541348 Danio rerio
738638 Pan troglodytes
100173923 Pongo abelii
100528563 Ictalurus punctatus
444344 Xenopus laevis
448392 Xenopus (Silurana) tropicalis
56647 Homo sapiens
66165 Mus musculus
512466 Bos taurus
477864 Canis lupus familiaris
100157478 Sus scrofa
361666 Rattus norvegicus
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