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The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Zusätzlich bieten wir Ihnen BAP1 Proteine (7) und BAP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 127 products:
Human Monoclonal BAP1 Primary Antibody für FACS, WB - ABIN258775
Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010
Human Polyclonal BAP1 Primary Antibody für IHC (p), WB - ABIN388948
Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011
Bap1 as a metabolic regulator in liver and pancreas.
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (zeige INO80 Antikörper) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (zeige VHL Antikörper) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (zeige VHL Antikörper) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (zeige VHL Antikörper) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (zeige GJB1 Antikörper) expression is in part related to induction of tight junctions through modulation of Magi1 (zeige CNKSR3 Antikörper) expression in an immortalized hepatic cell line.
ARIP1 (zeige MAGI2 Antikörper) and ARIP2 (zeige SYNJ2BP Antikörper) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (zeige HCFC1 Antikörper) and OGT (zeige OGT Antikörper) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Although there have been reports of sarcomas and meningiomas in patients affected with BAP1 (zeige RNF2 Antikörper) mutations, to our knowledge malignant peripheral nerve sheath tumors in this patient population have not been previously reported. We report a case of malignant peripheral nerve sheath tumor in a patient affected by a BAP1 (zeige RNF2 Antikörper) mutation.
Low BAP1 (zeige RNF2 Antikörper) expression is associated with lung cancer progression.
Study shows that the tumor suppressor gene breast cancer [BRCA]1-associated protein 1 (BAP1 (zeige RNF2 Antikörper)) is inactivated in 6 high-grade, rhabdoid meningiomas. In addition to patients with somatic BAP1 (zeige RNF2 Antikörper) loss, 2 patients carried germline mutations, indicating that such meningiomas can arise as part of the BAP1 (zeige RNF2 Antikörper) cancer predisposition syndrome.
Nine of the 32 (28.1%) iCCA (zeige PRRT2 Antikörper) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (zeige RNF2 Antikörper) mutations, two each (6.3%) of CACNA2D3 (zeige CACNA2D3 Antikörper) and RASSF1 (zeige RASSF1 Antikörper) mutations, and one each (3.1%) of ATG7 (zeige ATG7 Antikörper) and PLCD1 (zeige PLCD1 Antikörper) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
BAP1 (zeige RNF2 Antikörper) mutation, Copy Number Loss, and/or Loss of Protein Expression is associated with Malignant Peritoneal Mesotheliomas.
BAP1 (zeige RNF2 Antikörper) regulates IP3R3 (zeige ITPR3 Antikörper)-mediated Ca(2 (zeige CA2 Antikörper)+) flux to mitochondria suppressing cell transformation
Loss of BAP1 (zeige RNF2 Antikörper) expression is associated with lung adenocarcinoma.
Our data confirm the established role of BAP1 (zeige RNF2 Antikörper) as a tumor suppressor protein (zeige TP53 Antikörper) and is the first report where BAP1 (zeige RNF2 Antikörper) has been studied in pT1 (zeige ZNF77 Antikörper) clear cell renal cell carcinomas
Important role of BAP1 (zeige RNF2 Antikörper) in the survival of osteosarcoma cells.
Loss of BAP1 (zeige RNF2 Antikörper) expression is a rare event in non-small cell lung cancer.
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1