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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Zusätzlich bieten wir Ihnen Asporin Antikörper (49) und Asporin Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (zeige CD44 ELISA Kits)-AKT (zeige AKT1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits)-NF-kappaB (zeige NFKB1 ELISA Kits) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (zeige EGFR ELISA Kits) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (zeige OMD ELISA Kits), osteoglycin (zeige OGN ELISA Kits), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.
This meta-analysis shows that the ASPN D14, D13, and D15 (zeige MRPL16 ELISA Kits) alleles are not associated with the development of osteoarthritis in Europeans and Asians. [Meta-Analysis]
A meta-analysis suggest that the D-repeat of asporin gene (ASPN) may not be a major susceptibility locus in the Caucasian and Asian populations with knee osteoarthritis.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (zeige DCN ELISA Kits) and biglycan (zeige BGN ELISA Kits) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2 (zeige TLR2 ELISA Kits)- and TLR4 (zeige TLR4 ELISA Kits)-induced inflammatory responses and binding abilities to TLR2 (zeige TLR2 ELISA Kits) and TLR4 (zeige TLR4 ELISA Kits)
positively regulates FGF-2 (zeige FGF2 ELISA Kits) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (zeige MMRN1 ELISA Kits) and TGF-beta1 (zeige TGFB1 ELISA Kits) and thereby modulates interactions between TGF-beta (zeige TGFB1 ELISA Kits) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (zeige BMP2 ELISA Kits) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (zeige TGFB1 ELISA Kits) induces ASPN through Smad3 (zeige SMAD3 ELISA Kits) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (zeige BMP2 ELISA Kits) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (zeige OGN ELISA Kits) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1