Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) ELISA Kits

The protein encoded by DARS2 belongs to the class-II aminoacyl-tRNA synthetase family. Zusätzlich bieten wir Ihnen DARS2 Antikörper (36) und DARS2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus DARS2 DARS2 226539 Q8BIP0
Anti-Ratte DARS2 DARS2 304919 Q3KRD0
Anti-Human DARS2 DARS2 55157 Q6PI48
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Weitere ELISA Kits für DARS2 Interaktionspartner

Mouse (Murine) Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) Interaktionspartner

  1. DARS2 depletion in heart and skeletal muscle leads to the severe deregulation of mitochondrial protein (zeige COX6B2 ELISA Kits) synthesis followed by a strong respiratory chain deficit in both tissues.

Human Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) Interaktionspartner

  1. This study identified DARS2-associated leukoencephalopathy with hypomyelination with brainstem and spinal cord involvement and leg spasticity.

  2. 60 different DARS2 mutations were identified in 78 patients with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation, 13 of which have not been reported before

  3. Cognitive impairment seems to be common among patients with leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate and DARS2 mutations

  4. A comparison of biophysical properties of human mitochondrial aspartyl-tRNA synthetase (zeige DARS ELISA Kits), HsaDRS2, with them to those of a bacterial (E. coli) homolog, EcoDRS.

  5. Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase (zeige DARS ELISA Kits) in diverse way

  6. We describe two new cases of Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate with a novel pathogenic mutation in the DARS2 gene

  7. Case demonstrates that DARS2 mutation homozygosity is not lethal, as suggested earlier, but compatible with a rather benign disease course.

  8. Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA.

  9. A novel homozygous mutation of DARS2 may cause a severe LBSL (Leukoencephalopathy with brain stem and spinal cord involvement with lactate elevation) variant.

  10. This report describes two novel heterozygote composite mutations in the DARS2 gene

DARS2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).

Genbezeichner und Symbole assoziert mit DARS2

  • aspartyl-tRNA synthetase 2, mitochondrial (DARS2) Antikörper
  • aspartyl-tRNA synthetase 2, mitochondrial (dars2) Antikörper
  • aspartate--tRNA ligase, mitochondrial (LOC100547893) Antikörper
  • aspartyl-tRNA synthetase 2 (mitochondrial) (Dars2) Antikörper
  • 5830468K18Rik Antikörper
  • ASPRS Antikörper
  • LBSL Antikörper
  • MT-ASPRS Antikörper
  • RGD1308286 Antikörper
  • RP3-383J4.2 Antikörper
  • si:dkey-21n10.1 Antikörper

Bezeichner auf Proteinebene für DARS2

aspartyl-tRNA synthetase 2, mitochondrial , aspartyl-tRNA synthetase 2 (mitochondrial) , aspartyl-tRNA synthetase, mitochondrial , aspartyl-tRNA synthetase, mitochondrial-like , aspRS , aspartate--tRNA ligase, mitochondrial , aspartate tRNA ligase 2, mitochondrial

GENE ID SPEZIES
424408 Gallus gallus
469591 Pan troglodytes
490337 Canis lupus familiaris
571144 Danio rerio
707002 Macaca mulatta
100061003 Equus caballus
100145033 Xenopus (Silurana) tropicalis
100173764 Pongo abelii
100344833 Oryctolagus cuniculus
100401842 Callithrix jacchus
100547893 Meleagris gallopavo
100602031 Nomascus leucogenys
226539 Mus musculus
304919 Rattus norvegicus
55157 Homo sapiens
538772 Bos taurus
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