Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) ELISA Kits

ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Zusätzlich bieten wir Ihnen ASPM Antikörper (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Ratte ASPM ASPM 289054  
ASPM 259266 Q8IZT6
Anti-Maus ASPM ASPM 12316 Q8CJ27
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top ASPM ELISA Kits auf antikoerper-online.de

Showing 1 out of 1 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details

Weitere ELISA Kits für ASPM Interaktionspartner

Human Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) Interaktionspartner

  1. Abnormal cortical development in primary microcephaly was recapitulated with organoid culture in vitro using patient's induced pluripotent stem cells with ASPM mutation.

  2. Our study enlarges the collection of mutation data in ASPM-related microcephaly and offers new insight into the types and frequencies of the ASPM mutations. Further, our data highlight the clinical and imaging variability in patients with the same causative mutation, suggesting the involvement of additional (epigenetic) factors besides the primary locus.

  3. ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly.

  4. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  5. Through co-expression analysis, ASPM was identified and validated in association with the progression of Hepatitis C virus cirrhosis probably by regulating tumor-related phosphorylation.

  6. The results confirm that mutations in ASPM or WDR62 (zeige WDR62 ELISA Kits) are the major cause of autosomal recessive primary microcephaly in the Pakistani population.

  7. A novel homozygous splice-site variant in the ASPM gene was identified. The variant is predicted to have an effect on splicing. Human Splice Finder, an in silico tool, predicted skipping of exon 16 due to this variant. Skipping of exon 16 may change the order and number of IQ motifs in the ASPM protein leading to typical autosomal recessive primary microcephaly phenotype.

  8. contrary to current opinion, the cortical volume and surface area of patients with ASPM mutations is reduced depending on a regionally specific fashion and their cognitive profile reflects this heterogeneity.

  9. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as ASPM in lung cancer cells remaining after treatment, creating a more drug-resistant state.

  10. Gene-level tests showed that DRD2 (zeige DRD2 ELISA Kits) was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A (zeige AVPR1A ELISA Kits) with all three endophenotypes.

Mouse (Murine) Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) Interaktionspartner

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. Aspm and Wdr62 (zeige WDR62 ELISA Kits) interact genetically to control brain size, with mice lacking Wdr62 (zeige WDR62 ELISA Kits), Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone.

  3. Interaction between ASPM and the Cdk2 (zeige CDK2 ELISA Kits)/Cyclin E (zeige CCNE1 ELISA Kits) complex regulated the Cyclin (zeige PCNA ELISA Kits) activity by modulating its ubiquitination and localization into the nucleus.

  4. Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor.

  5. Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure teratogens.

  6. ASPM plays a critical role in meiotic spindle assembly and meiotic progression in mouse oocytes.

  7. AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons

  8. knockdown of Aspm results in decreased Wnt (zeige WNT2 ELISA Kits)-mediated transcription

  9. truncated Aspm proteins cause a massive loss of germ cells, resulting in a severe reduction in testis and ovary size accompanied by reduced fertility

  10. tissue distribution of Calmbp1 in fetal and adult mice

ASPM Antigen-Profil

Beschreibung des Gens

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ASPM

  • abnormal spindle microtubule assembly (Aspm) Antikörper
  • abnormal spindle microtubule assembly (ASPM) Antikörper
  • abnormal spindle microtubule assembly (aspm) Antikörper
  • asp (abnormal spindle)-like, microcephaly associated (Drosophila) (Aspm) Antikörper
  • ASP Antikörper
  • ASPM Antikörper
  • Calmbp1 Antikörper
  • D330028K02Rik Antikörper
  • MCPH5 Antikörper
  • Sha1 Antikörper

Bezeichner auf Proteinebene für ASPM

asp (abnormal spindle) homolog, microcephaly associated , calmodulin binding protein 1 , asp (abnormal spindle)-like, microcephaly associated , asp (abnormal spindle) homolog, microcephaly associated (Drosophila) , Abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly-associated protein , abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly protein , calmodulin-binding protein 1 , calmodulin-binding protein Sha1 , spindle and hydroxyurea checkpoint abnormal protein

GENE ID SPEZIES
289054 Rattus norvegicus
424354 Gallus gallus
449566 Pan troglodytes
100232605 Taeniopygia guttata
100379990 Xenopus (Silurana) tropicalis
259266 Homo sapiens
534849 Bos taurus
493695 Felis catus
443284 Ovis aries
480009 Canis lupus familiaris
711153 Macaca mulatta
12316 Mus musculus
Ausgewählte Anbieter für ASPM (ASPM) ELISA Kits
Haben Sie etwas anderes gesucht?