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Acts as a calcium-activated chloride channel. Zusätzlich bieten wir Ihnen ANO1 Antikörper (339) und ANO1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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TMEM16A expression was enhanced by 24-h treatment of IL-4 (zeige IL4 Proteine) in human nasal epithelial cells.
findings demonstrate that Ca2 (zeige CA2 Proteine)+ influx via store-operated CRAC channels is essential for CaCC (zeige CLCA1 Proteine) activation, chloride secretion, and sweat production in humans and mice.
TMEM16A activation as a sequential, direct, and Vm-dependent binding.
Ano1(0) without EAVK [Ano1(0)DeltaEAVK] has reduced sensitivity for intracellular calcium, attributable to slower kinetics. Differential expression of EAVK may function as a calcium-sensitive switch in the human stomach.
Gains of ANO1 is associated with oropharyngeal squamous cell carcinoma.
DOG1 is a novel marker for identifying intercellular canaliculi and is a potential immunomarker of myoepithelial cells specific to mammary glands, anogenital mammary-like glands and tumors originating therein.
Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 (zeige CLCA1 Proteine) or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 (zeige CLCA1 Proteine) stabilizes TMEM16A at the cell surface by preventing its internalization.
These results suggest that ANO1 Cl(-) channels may function as a transcriptional regulator of HER2 (zeige ERBB2 Proteine), and ANO1 inhibitors have potential in the treatment of BCA (zeige BLNK Proteine) patients with resistance to HER2 (zeige ERBB2 Proteine)-targeted therapy.
Endogenous ANO1 was associated with COPB1 (zeige COPB1 Proteine) in U251 glioblastoma cells, and silencing of COPB1 (zeige COPB1 Proteine) enhanced surface expression and whole-cell currents of ANO1 in these cells. Taken together, these data suggest that COPB1 (zeige COPB1 Proteine) negatively regulates ANO1 surface expression.
targeting TMEM16A improves response to biological therapies targeting EGFR (zeige EGFR Proteine)/HER family members
ANO1 immunoreactivity was observed in the presynaptic terminals of various retinal neurons, including photoreceptors
In this work we demonstrate that increasing the extracellular proton concentration from 10-10 to 10-5.5 m enabled TMEM16A activation. Furthermore, we show that this effect is voltage independent, caused by changes in the apparent open probability of the channel, and due to protonation of extracellular residue E623
The present study shows that ANO1 and CavL play a central role in the generation of slow waves, phasic contractions and tone in the internal anal sphincter and that this pathway can occur in the absence of stretch
We knocked out Ano1 to varying degrees in interstitial cells of Cajal (ICC) of adult mice. Partial knockout of Ano1 shortened the widths of electrical slow waves and Ca(2 (zeige CA2 Proteine)+) transients in myenteric ICC but Ca(2 (zeige CA2 Proteine)+) transient synchronicity was preserved. Near-complete knockout was necessary for transient desynchronization and loss of slow waves, indicating a large functional reserve of Ano1 in ICC.
Phosphorylation levels of P38 (zeige CRK Proteine) and JNK (zeige MAPK8 Proteine) in siRNA-TMEM16A group were lower than that of the Model group. Thus, TMEM16A is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.
To determine the role of ANO1 in physiological functions.
ANO1/TMEM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the lumen.
TMEM16A is a positive regulator of endothelial reactive oxygen species generation via Nox2 (zeige CYBB Proteine)-containing NADPH oxidase (zeige NOX1 Proteine), which induces endothelial dysfunction and hypertension.
Data indicate that anoctamin channel proteins ANO1 and ANO2 (zeige ANO2 Proteine) are expressed in the cerebellum.
Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).
anoctamin 1, calcium activated chloride channel
, Ca-activated chloride channel Tmem16A
, discovered on gastrointestinal stromal tumors protein 1
, oral cancer overexpressed 2
, transmembrane protein 16A (eight membrane-spanning domains)
, tumor-amplified and overexpressed sequence 2
, transmembrane protein 16A