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Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Zusätzlich bieten wir Ihnen Annexin A6 Proteine (20) und Annexin A6 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 152 products:
Human Monoclonal ANXA6 Primary Antibody für IF, IP - ABIN967890
Babiychuk, Draeger: Annexins in cell membrane dynamics. Ca(2+)-regulated association of lipid microdomains. in The Journal of cell biology 2000
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Human Monoclonal ANXA6 Primary Antibody für IF, IP - ABIN967891
Babiychuk, Palstra, Schaller, Kämpfer, Draeger: Annexin VI participates in the formation of a reversible, membrane-cytoskeleton complex in smooth muscle cells. in The Journal of biological chemistry 2000
Show all 5 Pubmed References
Human Polyclonal ANXA6 Primary Antibody für ICC, IF - ABIN4280822
Nakayama, Fukuda, Inoue, Nishida-Fukuda, Shirakata, Hashimoto, Higashiyama: Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin. in Molecular biology of the cell 2012
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Human Polyclonal ANXA6 Primary Antibody für WB - ABIN947559
Ramírez-Mata, Michalak, Mendoza-Hernández, León-Del-Río, González-Noriega: Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine ?-glucuronidase. in Experimental cell research 2011
Immunoprecipitation of the products obtained from the transcription/translation system using various anti-annexin A6 antibodies confirmed the presence of several isoforms and suggested that this protein might be present in different configurations.
AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release.
High ANXA6 expression is associated with neoplasms.
stable or transient AnxA6 overexpression in HuH7 cells led to elevated lipid droplet numbers/size and neutral lipid staining under control conditions
Annexin VI is enriched in calcifying valve interstitial cell derived-matrix vesicles from patients with end stage renal disease-induced hypercalcemia and aortic valve calcification.
These findings suggest that cancer-associated fibroblasts -tumor cell crosstalk supported by ANXA6+ EVs is predictive of pancreatic ductal adenocarcinoma aggressiveness, highlighting a therapeutic target and potential biomarker for pancreatic ductal adenocarcinoma.
The current study shows that AnxA6 is specifically reduced in human hepatocellular carcinoma suggesting a role of this protein in hepatocarcinogenesis.
Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1.
ANXA6 was detected as a novel systemic lupus erythematosus susceptibility gene, with several single-nucleotide polymorphisms (SNPs) contributing independently to the association with disease
ANXA6 is a EZH2 (zeige EZH2 Antikörper) target gene involving gastric cellular proliferation.
AnxA6 regulates IL-2 (zeige IL2 Antikörper) homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
morphological analysis of liver sections from annexin A6-KO mice revealed significantly lower lipid droplet numbers compared to wildtype animals
Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains
Transient knockdown of annexin A6 and calsequestrin 1 (zeige CASQ1 Antikörper) protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001).
Anxa6 is a modifier of muscular dystrophy and membrane repair after injury.
anxA6 inhibits Drp1 (zeige CRMP1 Antikörper) activity, and Ca(2 (zeige CA2 Antikörper)+)-binding to anxA6 relieves this inhibition to permit Drp1 (zeige CRMP1 Antikörper)-mediated mitochondrial
cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 (zeige LRP1 Antikörper) at neutral pH
Annexin VI regulation of myocardial contraction.
distinct functions of AnxA6 isoforms in membrane dynamics
AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase (zeige GUSB Antikörper).
The results showed that alkaline phosphatase activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II (zeige ANXA2 Antikörper) and VI content and (45)Ca uptake.
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
, annexin A6-like
, 67 kDa calelectrin
, annexin VI (p68)
, calcium-binding protein p68
, calphobindin II
, lipocortin VI
, annexin VI, p68
, CBP 65/67
, annexin VI
, calcium-binding protein 65/67
, calcium-binding protein CATA 65/67
, ANX VI
, annexin 6
, calcium- and phospholipid-binding protein
, lipid-dependent Ca(2+)-binding protein annexin VI