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ASB2 encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. Zusätzlich bieten wir Ihnen ASB2 Proteine (4) und ASB2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ASB2 Primary Antibody für WB - ABIN537369
Temmerman, Ma, Borges, Kubin, Liu, Derry, Jain: Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination. in Blood 2006
Using ASB2 conditional knockout mice.
Phosphorylation of serine 323 of ASB2 alpha by Erk (zeige EPHB2 Antikörper) kinases is critical for ASB2alpha-mediated degradation of FLNA (zeige FLNA Antikörper).
data therefore reveal ubiquitin acceptor sites in FLNa (zeige FLNA Antikörper) and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins.
Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK (zeige JAK3 Antikörper) proteins in hematopoietic cells
A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL (zeige MLL Antikörper) degradation and HOX (zeige MSH2 Antikörper) gene down-regulation.
By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch (zeige NOTCH1 Antikörper) could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation.
ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation.
This study identifies desmin (zeige DES Antikörper) as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin (zeige DES Antikörper) could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients
ASB2(-/-) immature dendritic cells exhibit reduced matrix-degrading function leading to defective migration.
ASB2beta is part of an active E3 ubiquitin ligase (zeige MUL1 Antikörper) complex and targets the actin-binding protein (zeige PFN1 Antikörper) filamin B (zeige FLNB Antikörper) for proteasomal degradation.
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ankyrin repeat and SOCS box-containing 2
, ankyrin repeat and SOCS box protein 2-like
, ankyrin repeat and SOCS box protein 2
, ankyrin repeat and SOCS box-containing protein 2a
, ankyrin repeat and SOCS box-containing protein 2
, ankyrin repeat-containing SOCS box protein 2