Angiomotin Like 2 Proteine (AMOTL2)

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Zusätzlich bieten wir Ihnen Angiomotin Like 2 Antikörper (19) und Angiomotin Like 2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
AMOTL2 51421 Q9Y2J4
Ratte AMOTL2 AMOTL2 65157  
AMOTL2 56332 Q8K371
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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AMOTL2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Angiomotin Like 2 (AMOTL2) Interaktionspartnern

Zebrafish Angiomotin Like 2 (AMOTL2) Interaktionspartner

  1. Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (zeige YAP1 Proteine) and the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) effector Lef1 (zeige LEF1 Proteine).

  2. amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.

  3. We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.

  4. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

  5. Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (zeige SRC Proteine), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.

Human Angiomotin Like 2 (AMOTL2) Interaktionspartner

  1. these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (zeige YAP1 Proteine) and AKT (zeige AKT1 Proteine) in liver size control and cancer prevention

  2. study reports for the first time that USP9X (zeige USP9X Proteine) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (zeige YAP1 Proteine) inhibition

  3. mTORC2 (zeige CRTC2 Proteine)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (zeige YAP1 Proteine) signaling.

  4. AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.

  5. Scaffold proteins angiomotin (Amot (zeige AMOT Proteine)) and angiomotin (zeige AMOT Proteine)-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP (zeige YAP1 Proteine) and TAZ (zeige TAZ Proteine) by preventing their nuclear translocation.

  6. These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (zeige AMOT Proteine) family members through direct phosphorylation.

  7. These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.

  8. AMOTL2 interacts with TAZ (zeige TAZ Proteine) and modulates transcriptional activity of TAZ (zeige TAZ Proteine).

  9. AMOTL2 is as a novel activator of LATS2.

  10. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

Mouse (Murine) Angiomotin Like 2 (AMOTL2) Interaktionspartner

  1. mTORC2 (zeige CRTC2 Proteine)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (zeige YAP1 Proteine) signaling.

  2. AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.

  3. Amot (zeige AMOT Proteine), Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri (zeige POSTN Proteine)-implantation period.

  4. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

  5. Data show that MUPP1 interacts with angiomotin (Amot (zeige AMOT Proteine)), JEAP/Amot (zeige AMOT Proteine)-like 1 and MASCOT/Amot (zeige AMOT Proteine)-like 2, and that all the Amot (zeige AMOT Proteine)/JEAP family proteins also interacted with Patj, a close relative of MUPP1.

Angiomotin Like 2 (AMOTL2) Protein Überblick

Protein Überblick

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

Genbezeichner und Symbole assoziert mit Angiomotin Like 2 Proteine (AMOTL2)

  • angiomotin like 1 (AMOTL1)
  • angiomotin like 2a (amotl2a)
  • angiomotin like 1 (amotl1)
  • angiomotin like 1 (LOC100348712)
  • angiomotin like 2 (AMOTL2)
  • angiomotin like 2 (amotl2)
  • angiomotin like 2 (Amotl2)
  • angiomotin-like 2 (Amotl2)
  • amotl2 Protein
  • AW549739 Protein
  • C79691 Protein
  • cb308 Protein
  • DKFZp468L222 Protein
  • jeap Protein
  • Lccp Protein
  • MASCOT Protein
  • mKIAA0989 Protein
  • sb:cb308 Protein
  • wu:fc41b07 Protein
  • wu:fc64c06 Protein

Bezeichner auf Proteinebene für Angiomotin Like 2 Proteine (AMOTL2)

angiomotin like 1 , angiomotin-like protein 1 , angiomotin like 2 , angiomotin-like 2a , angiomotin-like protein 1-like , angiomotin-like protein 2-like , Leman coiled-coil protein , angiomotin-like protein 2

GENE ID SPEZIES
428091 Gallus gallus
451491 Pan troglodytes
558920 Danio rerio
100145436 Xenopus (Silurana) tropicalis
100158429 Xenopus laevis
100172648 Pongo abelii
100348712 Oryctolagus cuniculus
100475663 Ailuropoda melanoleuca
718868 Macaca mulatta
100379727 Xenopus (Silurana) tropicalis
100523696 Sus scrofa
460712 Pan troglodytes
100540953 Meleagris gallopavo
51421 Homo sapiens
65157 Rattus norvegicus
56332 Mus musculus
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