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ACCN4 belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. Zusätzlich bieten wir Ihnen Amiloride-Sensitive Cation Channel 4, Pituitary Antikörper (55) und Amiloride-Sensitive Cation Channel 4, Pituitary Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Acid-sensing ion channel (ASIC (zeige ACCN2 ELISA Kits)) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression
Data show that transfected ASIC4 is targeted to the plasma membrane in CHO (zeige COL11A1 ELISA Kits)-K1 cells, where it associates with ASIC1a (zeige ACCN2 ELISA Kits) and downregulates exogenous ASIC1a (zeige ACCN2 ELISA Kits) expression.
This study demonstrated that ASIC4 may modulate fear and anxiety by counteracting ASIC1a (zeige ACCN2 ELISA Kits) activity in the brain.
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.
amiloride-sensitive cation channel 4, pituitary
, amiloride-sensitive cation channel 4, pituitary, isoform 1
, amiloride-sensitive cation channel 4-like
, acid-sensing ion channel 4
, amiloride-sensitive cation channel family member 4, pituitary
, brain sodium channel 4
, putative acid-sensing ion channel
, spinal chord ASIC