anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antikörper

ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Zusätzlich bieten wir Ihnen Amiloride-Sensitive Cation Channel 2, Neuronal Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ACCN2 79123 P55926
ACCN2 41 P78348
ACCN2 11419 Q6NXK8
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Top anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antikörper auf antikoerper-online.de

Showing 10 out of 120 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-ACCN2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>HT1080 cell lysate Host: Rabbit <br /> Target Name: ASIC1 <br /> Sample Tissue: MCF7 cell lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: ASIC1 Sample Tissue: Human MCF7 Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: ASIC1 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of ACCN2 Antibody (C-term) (ABIN653218) in CEM cell line lysates (35 µg/lane). ACCN2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB ACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Maus Ziege Unkonjugiert ELISA, WB Western Blot: ACCN2 Antibody [NBP2-42507] - Analysis of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Maus Maus HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$422.40
Details
Maus Maus FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$426.80
Details
Maus Maus Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$429.00
Details
Maus Maus Biotin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$431.20
Details
Maus Maus PE ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$432.30
Details

ACCN2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antikörper

  1. Mammalian Monoclonal ACCN2 Primary Antibody für ISt, IHC - ABIN1304544 : Lin, Sun, Chen: Genetic exploration of the role of acid-sensing ion channels. in Neuropharmacology 2015 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal ACCN2 Primary Antibody für ELISA, WB - ABIN4277576 : Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010 (PubMed)

Weitere Antikörper gegen Amiloride-Sensitive Cation Channel 2, Neuronal Interaktionspartner

Horse (Equine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaktionspartner

  1. Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (zeige ACCN1 Antikörper) differential properties; ACCN1 and ACCN3 (zeige ACCN3 Antikörper) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.

Human Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaktionspartner

  1. ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments

  2. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (zeige ACCN1 Antikörper), and acid-sensing ion channel 3 (zeige ACCN3 Antikörper) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.

  3. Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (zeige CA2 Antikörper)+)/PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)).

  4. Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.

  5. The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (zeige ADORA2A Antikörper) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian

  6. analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel

  7. Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The

  8. Putative GABAA (zeige GABRg1 Antikörper) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  9. A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (zeige ACTN1 Antikörper) was determined in glioma tumor cells.

  10. ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (zeige DCTN1 Antikörper)-235 relative to the knuckle helix.

Mouse (Murine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaktionspartner

  1. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (zeige PTPN2 Antikörper) Model of Parkinson Disease

  2. The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be

  3. nonselective cation channels ( channels consist of at least one alpha-ENaC (zeige SCNN1A Antikörper) and one or more acid-sensing ion channel 1a (ASIC1a) proteins.

  4. ASIC1a is an important mediator of AHR (zeige AHR Antikörper).

  5. Ca(2 (zeige CA2 Antikörper)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (zeige EDN1 Antikörper)-induced NFATc3 (zeige NFATC3 Antikörper) nuclear import and 2) the scaffolding protein PICK1 (zeige PICK1 Antikörper) is necessary for NFATc3 (zeige NFATC3 Antikörper) nuclear import.

  6. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (zeige GRIN1 Antikörper) (mGlu) receptor-induced increase in action potential firing.

  7. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (zeige ACCN1 Antikörper) subunits, but not ASIC1b, ASIC3 (zeige ACCN3 Antikörper) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.

  8. Studies with ASIC1a-ASIC2a (zeige ACCN1 Antikörper) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (zeige DNAJC5 Antikörper) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.

  9. differential surface trafficking of ASIC1a, ASIC2a (zeige ACCN1 Antikörper), and ASIC2b, was investigated.

  10. This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

Pig (Porcine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaktionspartner

  1. Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antigen-Profil

Protein Überblick

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Genbezeichner und Symbole assoziert mit ACCN2

  • acid sensing ion channel subunit 1 (ASIC1) Antikörper
  • acid sensing ion channel subunit 2 (ASIC2) Antikörper
  • acid sensing ion channel subunit 1 (asic1) Antikörper
  • acid sensing ion channel subunit 1 (Asic1) Antikörper
  • acid-sensing (proton-gated) ion channel 1 (Asic1) Antikörper
  • ACCN2 Antikörper
  • AI843610 Antikörper
  • ASIC Antikörper
  • ASIC1 Antikörper
  • ASIC1a Antikörper
  • B530003N02Rik Antikörper
  • BNaC2 Antikörper

Bezeichner auf Proteinebene für ACCN2

amiloride-sensitive cation channel 2, neuronal , amiloride-sensitive cation channel 1, neuronal , Amiloride-sensitive cation channel 2, neuronal , BNaC2 , acid-sensing ion channel 1 , brain sodium channel 2 , proton gated cation channel ASIC1 , Cation channel, amiloride-sensitive, neuronal, 2 , acid-sensing ion channel 1a protein , acid sensing ion channel , degenerin 2

GENE ID SPEZIES
451888 Pan troglodytes
100058355 Equus caballus
100194955 Salmo salar
100355858 Oryctolagus cuniculus
713320 Macaca mulatta
79123 Rattus norvegicus
41 Homo sapiens
11419 Mus musculus
100517467 Sus scrofa
426883 Gallus gallus
477612 Canis lupus familiaris
538244 Bos taurus
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